TY - JOUR AU - Welchinska, E.V. AU - Nizenkovskaya, I.V. AU - Sharykina, N.I. PY - 2019/10/29 Y2 - 2024/03/29 TI - Chemistry of 6-methyluracile and antitumour activity of its new derivatives JF - Farmatsevtychnyi zhurnal JA - Farm Zh VL - 0 IS - 4 SE - Practical pharmacy DO - UR - https://pharmj.org.ua/index.php/journal/article/view/785 SP - 87-91 AB - A new convenient methods for the preparation with 18-crown-6-complex as catalyst of original hete­rocycles on the base of 6-methyluracile and fluoric containing sintones — common anesthetic ftorotan and 1,1 -diethylcarboxy-2-chloro-2-threefluoro-methylethylene were described. The structure and composition of synthesized compound has been confirmed by data of elemental analysis, IR- and NMR 1H -spectra. It was discovered that compounds which synthesized — mono- and bis-derivatives of 6-methyluracile applies to a little toxic preparations: its LD50 are at the interval from 580 mg/kg to 465 mg/kg. A strongly antitumour effect of bis-derivative of 6-methyluracile on Lymphosarcoma Plissa tumour with growth relaxation of tumor mass 72,5 % (the criteria of considerable are ≥ 50 %) has been registered. ER -