TY - JOUR AU - Golovenko, N.Ya. AU - Maltsev, E.V. AU - Larionov, V.В. PY - 2019/10/29 Y2 - 2024/03/29 TI - The chemical hydrolysis kinetics for somnolent drug «Levana ІС» JF - Farmatsevtychnyi zhurnal JA - Farm Zh VL - 0 IS - 4 SE - Original Articles DO - UR - https://pharmj.org.ua/index.php/journal/article/view/783 SP - 79-82 AB - The kinetics of chemical hydrolysis for somnolent drug «Levana 1C» under acidic and alkaline pH had been studied. The method for chromatographic determination of unchanged compound and its hyd­rolysis product in the range 0.02—0.18 mg/cm3 was developed. It was found that under pH 3,45 during 6 hours there weren’t the noticeable hydrolysis of the drug, while under pH 8,33 the hydrolysis degree was 15 % (half-life time T1/2 — 40,3 hours). ER -