TY - JOUR AU - Kaplaushenko, A. G. PY - 2019/02/12 Y2 - 2024/03/29 TI - The study of pharmacokinetics of morpholinium 2-(5-(4-pyridyl)-4-(2-methoxyphenyl)-1,2,4-triazol-3-ylthio)acetate JF - Farmatsevtychnyi zhurnal JA - Farm Zh VL - 0 IS - 6 SE - Pharmacology DO - UR - https://pharmj.org.ua/index.php/journal/article/view/368 SP - 88-92 AB - Present-day medicine and pharmacy use a lot of drugs that belong to different classes of compounds. However, the creation of new high-efficient and low-toxic drugs with wide spectrum of biological activity has been and still is an important task of the pharmaceutical science. Heterocyclic compounds, namely, 1,2,4-thiazole derivatives cause great interest to this regard as potential biologically active substances.The main purpose of the work is the synthesis of low-toxic and highly-efficient compounds as well as the search of biologically active substances among them.The object of our study was morpholinum 2-(5-(pyridin-4-yl)-4-(2-methoxyphenyl)-1,2,4-triazol-3-ylthio)acetate (Tiometrizol). It is known that this compound is quite active in the biological aspect of the substance. In the course of our work we studied the pharmacodynamics of morpholinum 2-(5-(pyridin-4-yl)-4-(2-methoxyphenyl)-1,2,4-triazol-3-ylthio)acetate on rabbits. The analysis of the absorption spectra of serum samples, which have been obtained after administration of solution morpholinium 2-(5-(pyridin-4-yl)-4-(2-methoxyphenyl)-1,2,4-triazol-3-ylthio)acetate has been conducted and characteristic absorption band of the substance at 275 nm after 15 minutes has been registered.It is established by spectrophotometric studying of blood and urine of animals that potential medicine Tiometrizol generates the maximum concentration in blood after intravenous injection and after 24 hours it is not detected in blood also after 32 hours it is not detected in urine of animals. That is why this non-toxic medicine can be recommended for further testing. ER -