@article{Kaminskyy_Khyluk_Lesyk_2019, title={Search of new anticancer agent among 2,3-disubstituted 5-ylidene-1.3- thiazolidinones-4}, url={https://pharmj.org.ua/index.php/journal/article/view/744}, abstractNote={<p>The synthetic method of difficulty accessible 5-ylidene-2,3-diaryl-4-thiazolidones was worked out base on the utilization of 2,3-diaryl-4-thiazolidones in Knovenagel condensation using potassium tert- butylat as base-catalyst. The mentioned compounds were synthesized in one-pot tricomponent reaction. The efficiency of proposed approach for synthesis of 4-substituted l-thio-4-azaspiro[4,5]dekan-3-ones and their ylidene derivatives was shown. Investigation of anticancer activity newly synthesized compounds showed that ylidene derivatives (II, IV) possessed higher activity level in comparison with their synthetic precursors (I, III).</p&gt;}, number={6}, journal={Farmatsevtychnyi zhurnal}, author={Kaminskyy, D.V. and Khyluk, D.V. and Lesyk, R.B.}, year={2019}, month={Oct.}, pages={36-43} }