@article{Skrypska_Blinder_Yelenich_Lytvyn_Neshchadin_Obushak_Yagodinets_2019, title={Antimicrobial activity of n-heterocyclic compounds containing coumarin moiety}, url={https://pharmj.org.ua/index.php/journal/article/view/365}, abstractNote={<p>Coumarin derivatives with different heterocyclic systems in the position 3 exhibit antibacterial activity. The aim of the work was the synthesis of new coumarin containing heterocyclic ensembles , the study of physical and chemical properties and biological activity of these compounds. As the starting reagent 3-(4-acetylphenyl)-2<em>H</em>-2-chromenone (I) was used. This compound by the reaction of coumarin with 4-acetyl&nbsp;benzenediazonium chloride was synthesized. By bromination of compound (I) 3-[4-(2-bromoacetyl)phenyl]-2<em>H</em>-2-chromenone (II) was obtained. By the reactions of compound (II) with pyridine, 4-methylpyridine, quinoline, benzo[<em>f</em>]quinoline and triphenylphosphine a quaternary salts was prepared. Compound (II) reacts with binucleophilic reagents to form thiazole, imidazo[1,2-<em>a</em>]pyridine, imidazo[1,2-<em>a</em>]pyrimidine and imidazo[2,1-i]purine derivatives. On the base of experimental microbiological studies we have established that compound (II), 3-(4-imidazo[1,2-<em>a</em>]pyrimidin-2-ylphenyl)-2<em>H</em>-2-chromenone (XIII) and 3-[4-(1<em>H</em>-imidazo[2,1-<em>i</em>]purin-8-yl)phenyl]-2<em>H</em>-2-chromenone (XIV) exhibit antimicrobial activity against strain <em>S. aureus </em>ATCC 25923 at low concentrations. Compounds (II, XIV) and 4-(2-oxo-2-[4-(2-oxo-2<em>H</em>-3-chromenyl)phenyl]ethyl)benzo[f]quinolinium bromide (VI) exhibit antimicrobial activity against strain <em>B. subtilis </em>ATCC 6633.</p&gt;}, number={6}, journal={Farmatsevtychnyi zhurnal}, author={Skrypska, O. V. and Blinder, O. V. and YelenichО. V. and Lytvyn, R. Z. and Neshchadin, A. O. and Obushak, M. D. and Yagodinets, P. I.}, year={2019}, month={Feb.}, pages={69-77} }