Synthesis and investigation of antimicrobial activity of 1-phenyl-4-arylamino substituted 1,5-dihydropyrrol-2-ones.

  • S.G. Taran -
  • V.О. Zubkov -
  • O.V. Kiz -
  • N.V. Dubinina -
Keywords: l,5-dihydropyrrol-2,4-dione, 4-arylamino-l,5-dihydropyrrol-2-ones, antimicrobial activity

Abstract

In a search for new biologically active substances based on the structure of tetramic acid the synthesis of l-phenyl-4-arylamino substituted l,5-dihydropyrrol-2-ones has been performed and microbiological screening of these substances has been carry out. Only l-phenyl-4-(3-methylphenyl)amino- and 1-phe- nyl-4-(4-methylphenyl)amino-l-phenyl-l,5-dihydropyrrol-2-ones has showed moderate antimicrobial activity vs S. aureus and B. subtilis.

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Published
2009-06-25
How to Cite
Taran, S., Zubkov, V., Kiz, O., & Dubinina, N. (2009). Synthesis and investigation of antimicrobial activity of 1-phenyl-4-arylamino substituted 1,5-dihydropyrrol-2-ones. Farmatsevtychnyi Zhurnal, (3), 55-59. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/982
Section
Original Articles