Synthesis and evaluation of antitumor activity of 5-[2-(3,5- diaryl-4,5-dihydro-pyrazol-1-yl)-2-oxo-ethylidene]-2,4-thiazolidinediones
Abstract
Following reaction of 3,5-diaryl-4,5-dihydro-lH-pyrazoles and (2,4-thiazolidinedione-5-ylidene)-acetyl chloride 5-[2-(3,5-diaryl-4,5-dihydro-pyruzol-1-yl)-2-oxoethylidene]-2,4-thiazolidinediones were synthesized. Structure of synthesized compounds was confirmed by 1H spectra. Antitumor activity screening allowed us to identify «hit-compound» for next optimization of potential anticancer agents’ structure.
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