The effect of melatonin on the state of carbohydrate metabolism in alloxan diabetic rats
Abstract
The paper demonstrates that in the liver of alloxan diabetic rats with occult and overt diabetes, compared with the control value, took place changes the level of basal glycemia, glycosylated hemoglobin (Hba lc), pyruvic acid — in the blood; the activity of lactate dehydrogenase, glucose-6-phosphatase, the content of glycogen, the activity of pyruvate kinase and glucose-6-phosphate dehydrogenase — in the liver. A 6-week injection of melatonin in a dose of 10 mg/kg to the alloxan diabetic rats was conducive to a normalization of the indices of carbohydrate metabolism in the group of animals with occult and overt diabetes.
References
2. Gorodetsky VK // Clinical laboratory diagnostics. - 2006. - № 2. - P. 25—32.
3. A. Efimov // Medicines of Ukraine. - 2004. - № 9. - P. 30—33.
4. Karyagina I.Yu., Emanuel Yu.V. // Clinical laboratory diagnostics. - 2002. - № 5. - P. 25-32.
5. Melatonin in norm and pathology / Ed. F.I.Komarov, S.I.Rapopport, N.K.Malinovskaya, V.N.Apisimova. - M .: ID Medpraktika, 2004. - 524 p.
6. Meretsky VM // Medical chemistry. - 2007. - Vol. 9, No. 3. - P. 83-86.
7. Methods of biochemical research / Ed. Mikhail Prokhorova. - Leningrad: Leningrad Publishing House. Univ., 1982. - P. 239-240.
8. VK Grin, VY Mikhailichenko, AA Seleznev [etc.] // Experimental studies. - 2004. - № 2. - P. 326-332.
9. Pankov VI, Pichkar II - Kiev, 2007. - 258 p.
10. Radchenko OM // Problems of endocrine pathology. - 2008. - № 1. - P. 104—107.
11. Skripnik NV // Endocrinology. - 2008. - Vol. 13, No. 2. - P. 234—241.
12. Trufakin VA // Bulletin of the Russian Academy of Medical Sciences. - 2006. - № 9-10. - P. 121—127.
13. Shumeiko A.G. // Problems of endocrine pathology. - 2008. - № 3. - P. 49—54.
14. Kanter Mehmet, Uysal Hamdi, Karaca Turan, Sagmanligil Hulia Ozdemir // Arch. Toxicol. - 2006. - Vol. 80, 6. P. 362-369.
15. Elmar Peschke // J. of Pineal Research. - 2008. - 44. - P. 26-40.
This work is licensed under a Creative Commons Attribution 4.0 International License.