The effect of melatonin on the state of carbohydrate metabolism in alloxan diabetic rats

  • О.Yu. Kushnir -
  • I.F. Meshchyshen -
  • I.M. Yaremii -
Keywords: melatonin, alloxan diabetes, carbohydrate metabolism, liver, rats

Abstract

The paper demonstrates that in the liver of alloxan diabetic rats with occult and overt diabetes, compa­red with the control value, took place changes the level of basal glycemia, glycosylated hemoglobin (Hba lc), pyruvic acid — in the blood; the activity of lactate dehydrogenase, glucose-6-phosphatase, the content of glycogen, the activity of pyruvate kinase and glucose-6-phosphate dehydrogenase — in the liver. A 6-week injection of melatonin in a dose of 10 mg/kg to the alloxan diabetic rats was conducive to a normalization of the indices of carbohydrate metabolism in the group of animals with occult and overt diabetes.

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Published
2020-07-09
How to Cite
KushnirО., Meshchyshen, I., & Yaremii, I. (2020). The effect of melatonin on the state of carbohydrate metabolism in alloxan diabetic rats. Farmatsevtychnyi Zhurnal, (5), 119-123. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/927
Section
Original Articles