Actual questions of pharmaceutical development of intravenous solutions for infusions

  • N.I. Gudz’ -
  • R.S. Korytnyuk -
  • T.G. Kalynyuk -
  • S.B. Bilous -
Keywords: solutions for infusions, pharmaceutical development, physical and chemical properties, dosage form, technological process, packaging materials

Abstract

The approaches to the pharmaceutical development of intravenous solutions for infusions are given in the article. Pharmaceutical development is grounded with taking into account the nosology of disease, method of intravenous introduction and supposes the study of main physical and chemical, pharmacokin­etic and biological properties of active ingredients, choice of auxiliary substances and their concentration, determination and studying of functional characteristics of solutions for infusions, interaction of solution for infusion with packaging materials, determination of the critical stages of technological process etc. Such properties of active ingredients like solubility, lipophility, ionicity, chirality, polymorphism, molecular weight, chemical and spatial structure, molecular-mass distributing and antigenicity for colloidal carries, pyrogenisity etc. have influence on functional characteristics of finish products.

References

1. Antipova OE // Bulletin of pharmacology and pharmacy. - 2006. - № 8. - P. 72-80.
2. Gud NI Development of composition and scientifically grounded technology of energy polio and colloidal solutions for parenteral application: Abstract. dis .... cand .. format. Sciences: 15.00.01 / Kyiv Medical Academy. PL Shupik. - K., 2002. - P. 21.
3. State Pharmacopoeia of Ukraine / State Enterprise "Scientific Expert Pharmacopoeial Center". - Type 1. - Extra. 2. - X .: State Enterprise "Scientific Expert Pharmacopoeial Center", 2008. - 620 p.
4. Infusion therapy and clinical nutrition / Ed. prof. GN Khlyabich. - The Fresenius Company, 1992. - 795 p.
5. Campbell D., Spence A. A. Anesthesia, resuscitation and intensive care / Per. with English. - M .: Medicine, 2000. - 264 p.
6. Instruction 42-3.1: 2004. Quality guidelines. Medicines. Pharmaceutical development. - Kiev, 2004. - 16 p.
7. Instruction 42-3.6: 2004. Quality guidelines. Medicines. Excipients. - Kiev, 2004. - 12 p.
8. VP Pakhomov, OA Checha, OA Goroshko // Pharmaceutical Industry. - 2006. - № 6. - P. 69-72.
9. Redhead LV // Ukrainian. Journal of Hematology and Transfusion. - 2001. - № 2. - P. 49-51.
10. VI Sergienko, R. Jelliffe, and IB Bondareva. Applied Pharmacokinetics: Basics and Clinical Application. - M .: RAMS, 2003. - 208 p.
11. Pharmaceutical Encyclopedia / Head Ed. council and author of the foreword by VP Chernykh. - K .: Morion, F24 2005. - 848 p.
12. Pharmaceutical and medical-biological aspects of drugs / Ed. prof. IMPertseva. - Vinnitsa: New Book, 2007. - 728 p.
13. Yu. I. Feshchenko, N.I. Humeniuk. // Ukrainian. chemotherapy journal. - 2008. - № 1-2 (22).
14. Encyclopedia of pharmaceutical technology. Third Edition. Edited by James Swarbick. - New York, London: Informa healthcare.
15. Erixon M., WieslanderA., Linden T. et al. / / Peritoneal Dialysis International. - 2005. - № 6. - P. 583—590.
16. Erixon M., Linden T., Kjellstrand P., Carlson 0. et al. // Perit. Dial. Int. - 2004. - № 4. - P. 392—398.
17. Graham L. Patrick. Chemia medyczna. Podstawowe zagadneenia. Other wydanie. - Warszawa: Wydawnictwa naukowo-techniczne, 2003. - 697 s.
18. Hoste E.A., Colpaert K., Vanholder R.C. et al. // J. nephrol. - 2005. - № 3. - P. 303-307.
19. Julien Robertt M. An example of drug action a consice, a nontechnical guide to the actions, uses, and side effects of a psychoactive drug. - 7 th ed. - 1995. - 511 p.
20. Kjellstrand P., Martinson E., Wieslander A. et al. // Perit. Dial. Int. - 2001. - № 4. - P. 338—344.
21. Kjellstrand P., Erixon M. Wieslander A. et al. // Perit. Dial, Int. - 2004. - № 4. - P. 385—391.
22. Lim S. // Acta Med. Indones. - 2007. - № 3. - P. 145-150.
23. Linden T., Cohen A., Deppisch R etal. // Kidney Int. - 2002. - № 2. - P. 697—703.
24. Lynn E. Jensen, Olli Tuominen, jay M. Lan (US). US Patent 2006/186045 A1. Systems and methods for delivery of peritoneal dialysis (PD) solutions. - Application number 11340403; Filing date 26.01.2006. - Publication date 24.08.2006.
25. Martindale. The complete drug reference. Thirty-third edition. Edited by Sean C Sweetman. BPharm, MRPharmS. - 2002.
26. Voges M., Faict D., Lechien G., Taminne M. // Perit Dial Int. - 2004. - № 6. - P. 590—595.
27. Wu C.-S., Wong D.-P., Wong C.-Y., Lin Y.-F. / Am. J. Health-Syst. Pharm. - 2002. - Vol. 59, 16. P. 1537-1538.
Published
2020-07-09
How to Cite
Gudz’, N., Korytnyuk, R., Kalynyuk, T., & Bilous, S. (2020). Actual questions of pharmaceutical development of intravenous solutions for infusions. Farmatsevtychnyi Zhurnal, (5), 94-101. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/921
Issue
No. 5 (2009): Farmatsevtychnyi zhurnal
Section
Original Articles
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