An investigation of interaction of novocaine with fumed silica
Keywords:
novocaine, fumed silica, adsorption, TPD MS
Abstract
The interaction of anesthetic novocaine with a silica surface has been investigated by IR-spectroscopy and temperature-programmed desorption mass-spectrometry methods. The adsorption of novocaine depending on pH and concentration of equilibrium solution has been examined. The constant of adsorption equilibrium and value of boundary adsorption have been calculated. It has been determined, that thermolysis of novocaine on silica surface occurs in several stages.
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3. Kislyuk M.V., Rozanov V.V. // Kinetics and catalysis. - 1995. - T. 36, No. 1. - P. 89-98.
4. Kulik TV, Barvinchenko VN, Palyanitsa BB etc. // Journal. Phys. chemistry. - 2007. - T. 81, No. 1. - P. 88-95.
5. Kulik TV, Ishchenko VV, Palyanitsa BB etc. // Mass spectrometry. - 2007. - Vol. 4, No. 3. - P. 179-186.
6. Lebedev AT Mass spectrometry in organic chemistry. - M .: BINOM. Laboratory of knowledge. - 2003. - P. 493.
7. Loginova LP, Nesterenko O.Yu. // Bulletin of Kharkiv National University. - 2006. - Vin. 14 (37). - № 731. - P. 112-119.
8. Mashkovsky M.D. Medicines. - Part 1. - M .: Medicine, 1986. - P. 624.
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Published
2020-03-11
How to Cite
Dudik, O., Kulik, T., & Palyanitsa, B. (2020). An investigation of interaction of novocaine with fumed silica. Farmatsevtychnyi Zhurnal, (1), 70-75. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/870
Section
Original Articles
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