Sharp toxicness, antihypoxic with termoprotective properties and antiischemic activity of morfoliniy of a 2-(5-(4-pyrimidil)-4-(2-methoxyphenil)-l,2,4-triazole-3-ylthio) acetate
Keywords:
1,2,4-triazoles, toxicness, antihypoxic and antiischemic activity
Abstract
The study of sharp toxicness is conducted, to antihypoxic and antiischemic activity of a morfoliniy 2-(5-(4-pyridil)-4-(2-methoxyphenil)-l,2,4-triazole-3-ylthio) acetate. It is set that this matter can be recommended for further researches with the purpose of creation of new original medicinal preparation.
References
1. Belousova I.P. Pathogenetic substantiation of pharmacocorrection of hypoxic syndrome by xanthine derivatives: Abstract. diss .... Cand. honey. - Odessa, 2000. - 21 p.
2. Glantz S. Biomedical statistics / Trans. with English. Yu.A. Danilova, ed. NE Buzikashvili, DV Samoilov. - M .: Practice, 1999. - 459 p.
3. Preclinical drug research / Ed. AVStefanova. - K., 2002. - 567 p.
4. Lukyanchuk VD, Kaplaushenko AG, Renzyak S.Y. etc. // Zaporozhye. honey. . - 2008. - № 4 (49). - pp. 127-129.
5. Lukyanchuk VD, Savchenko LV, Nemytych OD Search and experimental study of potential antihypoxic agents: Guidelines. - State Science Center of the Ministry of Health of Ukraine, 2002. - 26 p.
6. Pat. 37922 Ukraine. Morpholinium 2- (5- (4-pyridyl) -4- (2-methoxyphenyl) -3-ylthio) acetate having anti-hypoxic activity with thermoprotective properties and its dosage forms / Kapuaghenko AG, Luk VN, Renzyak S.Ya., Knish E.G., Panasenko O.I. - Statement. 28.07.2008; - Publ. 10.12.2008, Bul.№ 23.
7. Pat. 37927 Ukraine. Morpholinium 2- (5- (4-pyridyl) -4- (2-methoxyphenyl) -3-ylthio) acetate exhibiting antioxidant and detoxifying activity / Kaplaushenko AG, Lukyanchuk VD, Panasenko O. I., Knysh EG, Chadova LV, Rysuhina NV - Statement. 28.07.2008; - Publ. 10/12/2008, Bul. № 23.
8. Pat. 7053093 USA, IPC8 C 07 D 471/04, A 61 K 31/437. Bicyclic and tricyclic heteroaromatic com¬pounds / Neurogen Corp .; Yuan Jun, Albaugh Pamela, Shaw Kenneth, Hutchison Alan. - № 10/352519; claimed 28.01.03; publ. 30.05.06; PPC 514 / 25.05.
9. Pat. 7105511 USA, IPC C 07 D 513/04, A 61 K 31/542. Fluorescent fused-ring triazoles that inhibit cell proliferation and uses respectively / Unit Lehigh Univ .; Lescin Jeffery D., Heindel Ned, Heck Diane [et al.]. - № 10/922300; claimed 19.08.04; publ. 09/12/06, PPC 514 / 222.8.
10. Pat. 7235659 USA, IPC C 07 D 239/00 (2006.01). Process for preparing substituted 5-aminopyrazole [4,3-e] -1,2,4-triazolo [1,5-c] pyrimidines / Schering Corp .; Kuo Shen-Chun, Tran Thanh, ZhangPengyi. - № 10/999048; claimed 11/29/04; publ. 26.06.07; PPC 544/251.
11. Pat. 7135572 USA, IPC8 C 07 D 401/04. Diaryl 1,2,4-triazole derivatives as a highly selective cyclo-oxygenase-2 inhibitor / CJ Corp .; Cho IL-hwan, Lim Jee-woong, Noh Ji-young [et al.]. - No. 11/224787; claimed 12.09.05; publ. 10/14/06; PPC 546 / 272.4.
12. WujecM., Kosikowska Urs., Paneth P., Malm A. // Heterocycles. - 2007. - Vol. 71 No. 12. P. 2617-2626.
13. Gundogdu-Kataburun Nolan, Benkli Kadriye, Tanali Yagmur // Eur. J. Med. Chem. - 2006. - Vol. 41, No. 5.-P.651-656.
2. Glantz S. Biomedical statistics / Trans. with English. Yu.A. Danilova, ed. NE Buzikashvili, DV Samoilov. - M .: Practice, 1999. - 459 p.
3. Preclinical drug research / Ed. AVStefanova. - K., 2002. - 567 p.
4. Lukyanchuk VD, Kaplaushenko AG, Renzyak S.Y. etc. // Zaporozhye. honey. . - 2008. - № 4 (49). - pp. 127-129.
5. Lukyanchuk VD, Savchenko LV, Nemytych OD Search and experimental study of potential antihypoxic agents: Guidelines. - State Science Center of the Ministry of Health of Ukraine, 2002. - 26 p.
6. Pat. 37922 Ukraine. Morpholinium 2- (5- (4-pyridyl) -4- (2-methoxyphenyl) -3-ylthio) acetate having anti-hypoxic activity with thermoprotective properties and its dosage forms / Kapuaghenko AG, Luk VN, Renzyak S.Ya., Knish E.G., Panasenko O.I. - Statement. 28.07.2008; - Publ. 10.12.2008, Bul.№ 23.
7. Pat. 37927 Ukraine. Morpholinium 2- (5- (4-pyridyl) -4- (2-methoxyphenyl) -3-ylthio) acetate exhibiting antioxidant and detoxifying activity / Kaplaushenko AG, Lukyanchuk VD, Panasenko O. I., Knysh EG, Chadova LV, Rysuhina NV - Statement. 28.07.2008; - Publ. 10/12/2008, Bul. № 23.
8. Pat. 7053093 USA, IPC8 C 07 D 471/04, A 61 K 31/437. Bicyclic and tricyclic heteroaromatic com¬pounds / Neurogen Corp .; Yuan Jun, Albaugh Pamela, Shaw Kenneth, Hutchison Alan. - № 10/352519; claimed 28.01.03; publ. 30.05.06; PPC 514 / 25.05.
9. Pat. 7105511 USA, IPC C 07 D 513/04, A 61 K 31/542. Fluorescent fused-ring triazoles that inhibit cell proliferation and uses respectively / Unit Lehigh Univ .; Lescin Jeffery D., Heindel Ned, Heck Diane [et al.]. - № 10/922300; claimed 19.08.04; publ. 09/12/06, PPC 514 / 222.8.
10. Pat. 7235659 USA, IPC C 07 D 239/00 (2006.01). Process for preparing substituted 5-aminopyrazole [4,3-e] -1,2,4-triazolo [1,5-c] pyrimidines / Schering Corp .; Kuo Shen-Chun, Tran Thanh, ZhangPengyi. - № 10/999048; claimed 11/29/04; publ. 26.06.07; PPC 544/251.
11. Pat. 7135572 USA, IPC8 C 07 D 401/04. Diaryl 1,2,4-triazole derivatives as a highly selective cyclo-oxygenase-2 inhibitor / CJ Corp .; Cho IL-hwan, Lim Jee-woong, Noh Ji-young [et al.]. - No. 11/224787; claimed 12.09.05; publ. 10/14/06; PPC 546 / 272.4.
12. WujecM., Kosikowska Urs., Paneth P., Malm A. // Heterocycles. - 2007. - Vol. 71 No. 12. P. 2617-2626.
13. Gundogdu-Kataburun Nolan, Benkli Kadriye, Tanali Yagmur // Eur. J. Med. Chem. - 2006. - Vol. 41, No. 5.-P.651-656.
Published
2020-03-11
How to Cite
Kaplaushenko, A., Lukyanchuk, V., Panasenko, A., Knysh, Y., Renzyak, S., & Chadova, L. (2020). Sharp toxicness, antihypoxic with termoprotective properties and antiischemic activity of morfoliniy of a 2-(5-(4-pyrimidil)-4-(2-methoxyphenil)-l,2,4-triazole-3-ylthio) acetate. Farmatsevtychnyi Zhurnal, (1), 62-65. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/868
Section
Original Articles
This work is licensed under a Creative Commons Attribution 4.0 International License.
