Comparative pharmakokinetics of new potential cerebroprotektor VITIN-1 on the stage of absorption in norm and at cerebral ischemia
Abstract
In the present work results of the pharmakokinetic researches of complex compound of germanium with oxyetilidendiphosphonic acid and pyracetamum (VITIN-1) in control and experimental rats. It is experimentally established that in conditions of ischemic stroke of cerebrum there is substantial modification of germaniumorganic compound’s pharmakokinetics parameters toward the acceleration of absorption process in a central blood flow, what the followings parameters testify to: constant of speed of absorption and period of semiabsorption.
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