Synthesis, structure and biological activity of aryl- and alcylamydes of 6-nitro-2-chlorbenzoic acid

  • S.G. Isaev -
  • O.A. Blyzniuk -
  • O.O. Pavley -
  • L.M. Alekseeva -
  • N.E. Sheveleva -
Keywords: synthesis, 6-nitro-2-chlorbenzoic acid, biological activity

Abstract

Preparative methods in one stage of receiving aleyl- and arylamides of 6-nitro-2-chlorbenzoic has been carried out. The composition of synthesized compounds was proved by the data of element, IR-, UV-, NMR-spectra and counter synthesis and the purity was controlled by the method of thin- layer chromatography.

It was established, that amides of 6-nitro-2-chlorbenzoic acid belong to low toxic compounds ac­cording to classification by K.K. Sydorov and have bile-expelling, membraneprotective, antioxidanty, diuretic, fungistatic activity. These investigations helped to determine some behavior among conformation and biological activity of these biologically compounds.

References

1. Andryukov KV Synthesis, properties and biological activity of mono (di) bromo-substituted anthranilic acid derivatives, study of the structure connection with action using ionization constants and quantum-chemical calculations: Abstract, diss. formats. of sciences. - Perm, 2006. - 17 p.
2. Preclinical drug research: Method, recommendations / Ed. Corresponding Member AMS of Ukraine
OV Stefanova. - K .: Avicenna, 2006. - 528 p.
3. Drogovoz SM, Isaev SG, Alekseeva LM etc. // Medication. - 2002. - № 1/2. - pp. 64-68.
4. Isaev SG, Pavli OO, Berezniakova NL etc. // Ibid. - 2005. - № 5/6. - P. 56-59.
5. Isaev SG // Pharmacist. . - 2000. - № 6. - P. 52-55.
6. Isaev SG, Yaremenko VD, Zupanets IA etc. // Bulletin of Pharmacy. - 1998. - № 2 (18). - pp. 18-20.
7. Kobzar N.P. Synthesis, structure, and biological activity of bromo- and sulfomoyl-substituted ortho-chlorobenzoic N-R-anthranilic acids and their derivatives: Dis .... Cand. formats. of sciences. - X., 2008. - 157 p.
8. Levitin EY, Antonenko OV, Kabachny VI etc. // Doctor. - 1999. - № 13. - P. 38—39.
9. Pavliy OO Synthesis, chemical transformations, biological activity of ortho-halogenbenzoic, N-phenylanthranilic acids and 9-aminoacridine derivatives: Abstract. diss, ... Cand. formats. of sciences. - X., 2008. - 20 p.
10. Pavli OO, Isaev SG, Sokurenko IA // Medication. - 2003. - № 5/6. - P. 82-85.
11. Pat. 61313A of Ukraine, IPC SO7C 237/00, A61K31 / 165. Ortho-halogen-benzoic acid derivatives exhibiting anti-inflammatory, analgesic, choleretic, antioxidant, antibacterial and fungistatic activity / OA Brizitsky, SG Isayev, EM Dreval and others. (Ukraine). - Publ. 11/17/03, Bul. № 14.
12. Pat. 48039 of Ukraine, IPC СО7С 237/00, А61К 31/165. 3 ', 4'-dimethylanilide of 2-chlorobenzoic acid, which exhibits antioxidant and choleretic activity / SG Isayev, IS Shulga, SM Drovoz and others. (Ukraine). - Publ. 08/15/02, Bul. № 8.
13. Luddens N., Lang N., Corry E. // European journal of Pharmacology. - 1998. - Hol. 344, Iss. 2/3. P. 269-227.
14. Peixoto F., Vicente J., Madeira V. // Biochem. Mol. Toxicol. - 2003. - Vol. 17, No. 3. - P. 185—192.
15. PetzingerE. // Dtsch. Ticrarztl. Wochenschr. - 1992 - Vol. 99, No. 10. P. 412-415.
16. Sugita Y., Nagao T., Unishidani T. // European Journal of Pharmacology - 1999. - Vol. 365, Iss.l. P. 77-89.
Published
2020-03-11
How to Cite
Isaev, S., Blyzniuk, O., Pavley, O., Alekseeva, L., & Sheveleva, N. (2020). Synthesis, structure and biological activity of aryl- and alcylamydes of 6-nitro-2-chlorbenzoic acid. Farmatsevtychnyi Zhurnal, (2), 40-44. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/842
Section
Original Articles

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