Synthesis, structure and biological activity of aryl- and alcylamydes of 6-nitro-2-chlorbenzoic acid
Abstract
Preparative methods in one stage of receiving aleyl- and arylamides of 6-nitro-2-chlorbenzoic has been carried out. The composition of synthesized compounds was proved by the data of element, IR-, UV-, NMR-spectra and counter synthesis and the purity was controlled by the method of thin- layer chromatography.
It was established, that amides of 6-nitro-2-chlorbenzoic acid belong to low toxic compounds according to classification by K.K. Sydorov and have bile-expelling, membraneprotective, antioxidanty, diuretic, fungistatic activity. These investigations helped to determine some behavior among conformation and biological activity of these biologically compounds.
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