Synthesis, structure and biological activity of aryl- and alcylamydes of 6-nitro-2-chlorbenzoic acid

  • S.G. Isaev -
  • O.A. Blyzniuk -
  • O.O. Pavley -
  • L.M. Alekseeva -
  • N.E. Sheveleva -
Keywords: synthesis, 6-nitro-2-chlorbenzoic acid, biological activity

Abstract

Preparative methods in one stage of receiving aleyl- and arylamides of 6-nitro-2-chlorbenzoic has been carried out. The composition of synthesized compounds was proved by the data of element, IR-, UV-, NMR-spectra and counter synthesis and the purity was controlled by the method of thin- layer chromatography.

It was established, that amides of 6-nitro-2-chlorbenzoic acid belong to low toxic compounds ac­cording to classification by K.K. Sydorov and have bile-expelling, membraneprotective, antioxidanty, diuretic, fungistatic activity. These investigations helped to determine some behavior among conformation and biological activity of these biologically compounds.

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Published
2020-03-11
How to Cite
Isaev, S., Blyzniuk, O., Pavley, O., Alekseeva, L., & Sheveleva, N. (2020). Synthesis, structure and biological activity of aryl- and alcylamydes of 6-nitro-2-chlorbenzoic acid. Farmatsevtychnyi Zhurnal, (2), 40-44. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/842
Issue
No. 2 (2010): Farmatsevtychnyi zhurnal
Section
Original Articles
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