Synthesis and biological properties of the γ-(R-phenyloxamido)-butanoic acids and γ-(R-phenylsulfoniloxamido)-butanoic acids
Keywords:
γ-(R-phenyloxamido)-butanoic acids, γ-(R-phenylsulfoniloxamido)-butanoic acids, the synthesis, the pharmacologic activity
Abstract
γ-(R-phenyloxamido)-butanoic acids and γ-(R-phenylsulfoniloxamido)-butanoic acids were synthesized. The pharmacologic reserches showed that majority of com-pounds synthesized displayes diuretic, anti-inflammatory and analgesic activity when the toxicity is low.
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2. Berkhin EB // Chemical formats. . - 1977 - Vol. 11, No. 1 5. P. 3-11.
3. Brand J., Enginton G. The use of spectroscopy in organic chemistry. - M .: Mir, 1976. - 276 p.
4. Gatsura VV Methods of primary pharmacological study of biologically active substances. - M .: Medicine, 1977. - 131 p.
5. Georgiants VA, Banna H. I., Savchenko VM // Bulletin of Pharmacy. - 2007. - № 3 (51). P. 7-11.
6. Preclinical drug research: Method, recommendations / Ed. OV Stefanova. - K .: Avicenna, 2001. - 528 p.
7. Awouters F., Megens A.A.N.R., Niemegeers C.J.E. et al. // Jap. Pharmacol. Therapy. - 1991 - Vol. 19. P. 73-89.
8. Chena M „Betz W.J. // Biophys. J. - 1991 - Vol. 59, 6. P. 1251-1260.
9. Collins K.S., Franzblau S.G. // Antimicrob. Agents and Chemotherapy. - 1997 - Vol. 41. - P. 1004— 1009.
10. Gentry C., Melarange R., Durie M. et al. // Clin. Friend. Invest. - 1996 - Vol. 11, No. 1 1. R. 49-59.
11. Geerts W.H., Sayr M. // N. Engl. J. Med. - 1996. - №36. P. 701-707.
12. Haykawa J., Ando S.H. // J. Jap. Dent. Mater. - 1997 - Vol. 7, No. 1 7. P. 79-82.
13. Janyian M. // J. of Pharmac. Care in Pain and Symptom Control. - 1999. - Vol. 7, No. 1 4. P. 37-46.
14. Morgenstern O. // Ibid. - 2000. - Vol. 50, No. 1 12. P. 871-891.
15. Negwer M. Organic-chemical drugs and their synonyms (an international survey). - Berlin: Academie Verlag, 1994. - Vol. I. - 2855 p.
Published
2020-03-11
How to Cite
Georgiyants, V., Bannaya, N., Savchenko, V., & Bannyi, I. (2020). Synthesis and biological properties of the γ-(R-phenyloxamido)-butanoic acids and γ-(R-phenylsulfoniloxamido)-butanoic acids. Farmatsevtychnyi Zhurnal, (2), 34-40. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/841
Section
Original Articles
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