Actual questions of pharmaceutical development of semi-solid preparations for topical use
Keywords:
semi-solid preparations, pharmaceutical development, dosage form, components, technological process, packaging materials
Abstract
The approaches to the pharmaceutical development of semi-solid preparations are given in the article. Pharmaceutical development is grounded with taking into account the particularity of penetration of substances through the skin and supposes the study of main physical-chemical and pharmacokinetic properties of active ingredients, selection of auxiliary substances and their concentration, determination and studying of functional characteristics of dosage form, interaction of preparation with packaging materials, determination of the critical stages of technological' process, etc.
The algorithm of pharmaceutical development of semi-solid preparations is developed.
References
1. Antipova OE // Bulletin of pharmacology and pharmacy. - 2006. - № 8. - P. 72-80.
2. Bezuglai EP, Lyapunov NA, Bovtenko VA // Pharmacom. - 2008. - № 4. - P.75-82.
3. Golovenko M., Borisyuk I. // Bulletin of pharmacology and pharmacy. - 2006. - № 5. - P. 2—9.
4. Gudz OV // Doctor. - 1999. - № 4. - P.45—46.
5. State Pharmacopoeia of Ukraine. - X .: RIREG, 2001. - 556 p.
6. State Pharmacopoeia of Ukraine. Appendix II. - X .: State Enterprise "Scientific Expert Pharmacopoeial Center", 2008, - 620 p.
7. Danube OV, Khemerova KG, Lyapunov MO etc. // Pharmacom. - 2008. - № 1. - P. 38 - 43.
8. Logachev VK, // Visn. pharmacy. - 2002. - No. 2 (PA). - pp. 50-51.
9. Lyapunov NA, Zhemerova EG, Bezuglai EP etc. // Pharmacy. - 2004. - № 1. - P. 13—15.
10. Instruction 42-3.1: 2004. Quality guidelines. Medicines. Pharmaceutical development. - K., 2004. - 15 sec.
11. Oxidative stress and antioxidants: body, skin, cosmetics. / Under the general edit. A. Petrukhina. - M .: LLC “Firm KLAVEL”, 2006. - 288 p.
12. Drug Technology and Standardization: Collection of Scientific Papers of the State Scientific Center for Medicinal Products in two volumes.
Volume 1 / Ed. V.P.Georgievsky, F.A.Konev. - X .: Rireg Ltd., 1996. - 784 p.
13. Tikhonov OI, Bogutskaya OE // Vis. pharmacy. - 2001. - № 3. - P. 55.
14. Pharmaceutical and biological aspects of ointments / Ed. IMPertseva. - X .: Publishing House of NFaU: "Golden Pages", 2003. - 288,
15. Pharmaceutical and medical-biological aspects of drugs / Ed. prof. IMPertseva. - Vinnitsa: New Book, 2007. - 728p.
16. Chugasova VA // Cosmetics & Medicine. - 1998. - № 2. - P. 18-23.
17. Beliveau S., Gaudreault R., Goulet L. et al. // J. Cutan. Med. Surg. - 2008. - Vol. 12, Iss. 1. P. 27-30.
18. Borräs-Blasco J., Diez-Sales O., Lopez A. et al. // Int. J. Pharmaceutics. - 2004. - Vol. 269, Iss. 1. P. 121-129.
19. Council Directive 76/768 / EEC on the approximation of the laws of the Member States relating to cosmetic products. - 76 p. / www.fda.gov.
20. Dermatological and transdermal formulations / Edited by Kenneth A. Walters. - New York - London. - 2007. - 565 p.
21. Encyclopedia of pharmaceutical technology. Third Edition. / Edited by J.Swarbick. - New York, Lon¬don: Informa healthcare, 2007 - 1171 p.
22. Osterberg R., See N. // Int. J. Toxicol. - 2003. - Vol.22, Iss.5. P. 377-380.
23. Roland I., Piel G., Delattre L. et al. // Int. J. Pharmaceutics. - 2003. - Vol. 263, Iss. 1-2 - P. 85-94.
24. Schafer-Körting M., Mehnert W., Körting H. // Advanced Drug Delivery Reviews. - 2007. - № 59. - P. 427-443.
2. Bezuglai EP, Lyapunov NA, Bovtenko VA // Pharmacom. - 2008. - № 4. - P.75-82.
3. Golovenko M., Borisyuk I. // Bulletin of pharmacology and pharmacy. - 2006. - № 5. - P. 2—9.
4. Gudz OV // Doctor. - 1999. - № 4. - P.45—46.
5. State Pharmacopoeia of Ukraine. - X .: RIREG, 2001. - 556 p.
6. State Pharmacopoeia of Ukraine. Appendix II. - X .: State Enterprise "Scientific Expert Pharmacopoeial Center", 2008, - 620 p.
7. Danube OV, Khemerova KG, Lyapunov MO etc. // Pharmacom. - 2008. - № 1. - P. 38 - 43.
8. Logachev VK, // Visn. pharmacy. - 2002. - No. 2 (PA). - pp. 50-51.
9. Lyapunov NA, Zhemerova EG, Bezuglai EP etc. // Pharmacy. - 2004. - № 1. - P. 13—15.
10. Instruction 42-3.1: 2004. Quality guidelines. Medicines. Pharmaceutical development. - K., 2004. - 15 sec.
11. Oxidative stress and antioxidants: body, skin, cosmetics. / Under the general edit. A. Petrukhina. - M .: LLC “Firm KLAVEL”, 2006. - 288 p.
12. Drug Technology and Standardization: Collection of Scientific Papers of the State Scientific Center for Medicinal Products in two volumes.
Volume 1 / Ed. V.P.Georgievsky, F.A.Konev. - X .: Rireg Ltd., 1996. - 784 p.
13. Tikhonov OI, Bogutskaya OE // Vis. pharmacy. - 2001. - № 3. - P. 55.
14. Pharmaceutical and biological aspects of ointments / Ed. IMPertseva. - X .: Publishing House of NFaU: "Golden Pages", 2003. - 288,
15. Pharmaceutical and medical-biological aspects of drugs / Ed. prof. IMPertseva. - Vinnitsa: New Book, 2007. - 728p.
16. Chugasova VA // Cosmetics & Medicine. - 1998. - № 2. - P. 18-23.
17. Beliveau S., Gaudreault R., Goulet L. et al. // J. Cutan. Med. Surg. - 2008. - Vol. 12, Iss. 1. P. 27-30.
18. Borräs-Blasco J., Diez-Sales O., Lopez A. et al. // Int. J. Pharmaceutics. - 2004. - Vol. 269, Iss. 1. P. 121-129.
19. Council Directive 76/768 / EEC on the approximation of the laws of the Member States relating to cosmetic products. - 76 p. / www.fda.gov.
20. Dermatological and transdermal formulations / Edited by Kenneth A. Walters. - New York - London. - 2007. - 565 p.
21. Encyclopedia of pharmaceutical technology. Third Edition. / Edited by J.Swarbick. - New York, Lon¬don: Informa healthcare, 2007 - 1171 p.
22. Osterberg R., See N. // Int. J. Toxicol. - 2003. - Vol.22, Iss.5. P. 377-380.
23. Roland I., Piel G., Delattre L. et al. // Int. J. Pharmaceutics. - 2003. - Vol. 263, Iss. 1-2 - P. 85-94.
24. Schafer-Körting M., Mehnert W., Körting H. // Advanced Drug Delivery Reviews. - 2007. - № 59. - P. 427-443.
Published
2020-03-11
How to Cite
Bilous, S., Kalynyuk, T., & Gudz’, N. (2020). Actual questions of pharmaceutical development of semi-solid preparations for topical use. Farmatsevtychnyi Zhurnal, (2), 16-27. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/839
Section
Management, marketing and logistics
This work is licensed under a Creative Commons Attribution 4.0 International License.
