Use of computer mathematical modelling in development of the dose regimen of coordinative germanium compound with niconinamidum in conditions of hypoxic syndrome
Keywords:
dose regimen, mathematical modelling, coordination compound of germanium with nicotin- amidum, hypoxic syndrome
Abstract
Pharmacometric researches for determination of an optimum dose regimen of coordination compound of germanium with nicotinamidum (MIGU-2) permited to establish that introduction of this potential antihypoxic agent in a doze of 151,5 mg/kg in 72,72 minutes before modelling of a pathological condition provid maximum survival of rats in conditions of experiment.
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3. Preclinical drug research: Method. Recommendations / Ed. Corresponding Member Academy of Medical Sciences of Ukraine OV Stefanov. - K .: Avicenna, 2002. - 567 p.
4. Ershov SV // Labor protection. - 2007. - № 8. - P. 15-19.
5. Karnauh NG, Petrov GA, Dvornichenko GB // Ukrainian. . on occupational health problems. - 2006. - № 2. - P. 3-7.
6. GI Krasovsky, GF Filaretov, Experimental planning. - Mn .: Publishing House of BSU, 1982. - 302 p.
7. Lysenkov AN Mathematical methods of planning multifactor biomedical experiments. - M .: Medicine, 1979. - 344 p.
8. Lukyanchuk VD, Bibik O.Yu. // Odessa honey. . - 2000. - T. 61, No. 5. - P. 13-15.
9. Lukyanchuk VD, Korobkov OA, Kravets DS // Medication. - 2001. - № 1-2. - P. 94-98.
10. Lukyanchuk VD, Kravets DS // Ukrainian. honey. almanac. - 1999. - Vol. 2, No. 4. - P. 73-75.
11. Lukyanchuk VD, Tkachenko EV, Kravets DS. // Medication. - 2004. - № 1-2. - P. 77-81.
12. Maksimov VN A multifactorial experiment in biology. - Moscow: Moscow State University, 1980. - 279 p.
13. German OD, Seifullin 1.Y., Gudenko OP, Kravets DS. // Pharmacist. . - 2002. - № 4. - P. 86-90.
14. Rafaeles EE, Nikolaev NI Some methods of planning mathematical analysis of biological experiments. - K .: Sciences, Thought, 1971 - 157 p.
15. LV Savchenko Experimental substantiation of the ways of medical prophylaxis of closed hypoxia in a heated microclimate: Abstract. diss .... Dr. honey. of sciences. - K., 1999. - 35 p.
Published
2019-10-29
How to Cite
Lukyanchuk, V., Vitokhina, N., & Kravets, D. (2019). Use of computer mathematical modelling in development of the dose regimen of coordinative germanium compound with niconinamidum in conditions of hypoxic syndrome. Farmatsevtychnyi Zhurnal, (3), 94-98. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/807
Section
Original Articles
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