Chronic toxicness of morfoliniy of a 2-(5-(4-pyridil)-4- (2-methoxyphenil)- l,2,4-triazole-3-ilthio) acetate

  • A.G. Kaplaushenko -
  • A.I. Panasenko -
  • Ye.G. Knysh -
  • I.F. Belenichev -
  • A.A. Svintozelskiy -
Keywords: 1,2,4-triazoles, chronic toxicity

Abstract

Results, studies of chronic toxicity of a morfoliniy 2-(5-(4-pyridil)-4-(methoxyphenil)-l,2,4-triaz- ole-3-thio)acetate at the protracted application testifies to absence for him of properties of functional or physiological cumulation at the use of this matter even in the dose of 1 g/kg.

References

1. Berezovsky VA Method of accelerated statistical processing in medical research // Methods of medical statistics. - M .: Nauka, 1975. - P. 41-46.
2. Dekhtyar G.Ya. Electrocardiographic diagnosis. - M .: Medicine, 1966. - 542 p.
3. Preclinical drug research / Ed. AVStefanova. - K., 2002. - 567 p.
4. Zapadnyuk IP, Zapadnyuk VI, Zakharin EA, Zapadnyuk BV Laboratory animals. Breeding, keeping, use in experiment. - Kiev: High School, 1983. - 382 p.
5. Kolb VG, Kamyshnikov VS Directory of Clinical Chemistry.-Minsk: Belarus, 1982. - 266 p.
6. VV Menshikov, LN Delectorskaya. Laboratory research methods in the clinic: Handbook ed. VV Menshikov. - M .: Medicine, 1987. - 368.
7. Pat. 37922 Ukraine. Morpholinium 2- (5- (4-pyridyl) -4- (2-methoxyphenyl) -3-ylthio) acetate having antihypoxic activity with thermoprotective properties and its dosage forms / Kapaushenko AG, Lukyanchuk VD, Renzyak SY, Knysh EG, Panasenko OI - Statement. 28.07.2008; - Publ. 10.12.2008. - Bull. № 23.
8. Pat. 37927 Ukraine Morpholinium 2- (5- (4-pyridyl) -4- (2-methoxyphenyl) -3-ylthio) acetate exhibiting antioxidant and detoxifying activity / Kaplaushenko AG, Lukyanchuk VD, Panasenko OI, Knish EG, Chadova LV, Rysuhina NV - Statement. 28.07.2008; - Publ. 10.12.2008. - Bull. № 23..
9. Predtechensky V.E. A guide to clinical laboratory research. - M .: Medicine, 1964. - 960 p.
10. DS Sarkisov, PI Remezov Reproduction of human diseases in an experiment. - M .: Medicine, 1960. - P. 189.
11. Trachtenberg IM, Sova RE, Sheftel VA, Onyienko FA Indicators of norm in laboratory animals in toxicological experiment. - M .: Medicine, 1978 - 1967 p.
Published
2019-10-29
How to Cite
Kaplaushenko, A., Panasenko, A., Knysh, Y., Belenichev, I., & Svintozelskiy, A. (2019). Chronic toxicness of morfoliniy of a 2-(5-(4-pyridil)-4- (2-methoxyphenil)- l,2,4-triazole-3-ilthio) acetate. Farmatsevtychnyi Zhurnal, (3), 81-88. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/805
Section
Original Articles

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