Determ tion with bromothymol blue
Keywords:
spectrophotometry, bromothymol blue, fluconazole, sulphonphthalein dyes, quantitative determination
Abstract
A new precise and sensitive spectrophotometric method for the quantitative determination of fluconazole in pharmaceutical preparations based on the reaction with bromothymol blue is developed. Validation characteristics such as linearity, application range, specificity, precision, accuracy and robustness are also determined. The method is valid according to these characteristics.
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2. Abdel-Moety E.M., Khattab F.I., Kelani K.M., AbouAl-Alamein A.M. // Farmaco. - 2002. - Vol. 57, No. 11. P. 931-938.
3. Ayub A.C., Vianna-Soares C.D., Ferreira L.A. // J. Chromatogr. Sci. - 2007. - Vol. 45, 5. P. 286-290.
4. Cardoso S.G., Ieggli C.V., Pomblum S.C. // Pham. - 2007. - Vol. 62, No. 1. - P. 34—37.
5. Eerkes A., Wilson Z, Naidong S., Naidong W. // J. Pharm. Biomed. Anal. - 2003. - Vol. 31, 5. P. 917-928.
6. Ekiert R.J., Krzek J. // Acta Pol Pharm. - 2009. - Vol. 66, No. 1. - P. 19-24.
7. Erk N., Pham. - 2007. - Vol. 59 No. 3. P. 183-186.
8. Kim S.S., Im H.T, Kang I.M. et al. // J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. - 2007. - Vol. 852, No. 1-2. P. 174-179.
9. Mostafa S. / M. El-Sadek, E. A. Alla // J. of Pharm, and Biom. Anal. - 2002, - № 28. - P. 173—180.
10. Rahman N., Hejaz-Azmi S. N. // J. of Pharm. and Biom. Anal. - 2000. - № 24. - P. 33-41.
11. Wattananat 71, Akarawut W. // Biomed. Chromatogr. - 2006. - Vol. 20, No. 1. - P. 1-3.
12. Zhang S., Mada S. R., Torch M. et al. // Ther. Drug Monit. - 2008. - Vol. 30, No. 3. - P. 314—319.
Published
2019-10-29
How to Cite
Burlaka, J., Tarkhanova, O., Vasjuk, S., & Keytlin, I. (2019). Determ tion with bromothymol blue. Farmatsevtychnyi Zhurnal, (3), 69-75. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/803
Section
Original Articles
This work is licensed under a Creative Commons Attribution 4.0 International License.
