Chemistry of 6-methyluracile and antitumour activity of its new derivatives
Abstract
A new convenient methods for the preparation with 18-crown-6-complex as catalyst of original heterocycles on the base of 6-methyluracile and fluoric containing sintones — common anesthetic ftorotan and 1,1 -diethylcarboxy-2-chloro-2-threefluoro-methylethylene were described. The structure and composition of synthesized compound has been confirmed by data of elemental analysis, IR- and NMR 1H -spectra. It was discovered that compounds which synthesized — mono- and bis-derivatives of 6-methyluracile applies to a little toxic preparations: its LD50 are at the interval from 580 mg/kg to 465 mg/kg. A strongly antitumour effect of bis-derivative of 6-methyluracile on Lymphosarcoma Plissa tumour with growth relaxation of tumor mass 72,5 % (the criteria of considerable are ≥ 50 %) has been registered.
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