2-R-(4,6dimorpholine-4-yl-l,3,5-triazine-2-yl)-N-methylhydrazinecarbothioami de derivatives synthesis and antioxidant activity evaluation

  • Y.V. Renkas -
  • V.V. Sukhoveev -
  • S.O. Smolsky -
  • A.V. Kurach -
  • A.M. Demchenko -
Keywords: antioxidant, prooxidant, 1,3,5-triazin, derivatives of 2-R-(4,6-dimorpholine-4-yl-l,3,5-triazine- 2-yl)-N-methylhydrazinecarbothioamide, nitrogen monoxide, nitrosative stress, oxidative stress

Abstract

The research of new antioxidants among the new, first time synthesized derivatives of 2-R-(4,6- dimorpholine-4-yl-l,3,5-triazine-2-yl)-N-methyl-hydrazinecarbothioamide is described in the paper. In vitro pharmacological research has shown, that these new compounds perform significant antioxidant activity compared to standard antioxidant which is 4-methyl-2,6-di-tert-butylphenol (E321). Antioxidant properties of the synthesized compounds have been evaluated on the basis of nitric oxide (NO) radical absorption effect. These compounds can be valuable starting points in the drugs development, that operate under oxidative stress conditions.

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Published
2019-10-29
How to Cite
Renkas, Y., Sukhoveev, V., Smolsky, S., Kurach, A., & Demchenko, A. (2019). 2-R-(4,6dimorpholine-4-yl-l,3,5-triazine-2-yl)-N-methylhydrazinecarbothioami de derivatives synthesis and antioxidant activity evaluation. Farmatsevtychnyi Zhurnal, (4), 68-75. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/781
Section
Original Articles