Neuroapoptosis and neuroprotection by NMDA-receptors antagonists
Keywords:
neuroapoptosis, glutamate «excitotoxycity’», riluzole, amantadin
Abstract
The phenomene apoptotic death of neurons are observed at the different pathological states — any displays of ischemic and traumatic damages of nervous tissue, including violations of spinal cord, demential changes, related to development of Al’zgeymer disease, Parkinson’s disease, senile demention, born pathologies of brain and other. Information of comparative researches of neuroprotector action of the known NMDA-receptors antagonists riluzole (basic preparation is in treatment of lateral amyotrophic sclerosis) and amantadine (antiparcinsonic preparation) is resulted in the conditions of glutamate «excitotoxycity» in vitro.
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Published
2019-10-29
How to Cite
Mamchur, V., KravchenkoК., Besedin, A., & Kulish, U. (2019). Neuroapoptosis and neuroprotection by NMDA-receptors antagonists. Farmatsevtychnyi Zhurnal, (4), 44-49. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/776
Section
Original Articles
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