Neuroapoptosis and neuroprotection by NMDA-receptors antagonists

  • V.I. Mamchur -
  • К.A. Kravchenko -
  • A.M. Besedin -
  • U.M. Kulish -
Keywords: neuroapoptosis, glutamate «excitotoxycity’», riluzole, amantadin

Abstract

The phenomene apoptotic death of neurons are observed at the different pathological states — any displays of ischemic and traumatic damages of nervous tissue, including violations of spinal cord, demential changes, related to development of Al’zgeymer disease, Parkinson’s disease, senile demention, born pathologies of brain and other. Information of comparative researches of neuroprotector action of the known NMDA-receptors antagonists riluzole (basic preparation is in treatment of lateral amyotrophic sclerosis) and amantadine (antiparcinsonic preparation) is resulted in the conditions of glutamate «excitotoxycity» in vitro.

References

1. Gubsky YI, Belenichev IF, Kovalenko SI etc. // Contr. prob. toxicol. - 2004. - № 2. - P. 8-16.
2. Illustrated Medical Dictionary of Dorland (29 th. Ed.) In two volumes / ed. P. Jules, B. Zimenkovsky. - 2002. - T. 1. - P. 154. - 2.
3. Levitsky EL, Belenichev IF, Gubsky Yu.I. in other // Journal. academy. honey. of Sciences of Ukraine. - 2008. - Vol. 14, No. 2. - P. 203-218.
4. Prokhorov MI Modern methods of biochemical research (lipid and energy exchange) / Ed. Mikhail Prokhorova. - L .: Publisher Len. Univ., 1982. - 272 p.
5. Cao G „Xing J., Xiao X. et al. //]. Neurosci. - 2007. - N 27. - P. 9278-9293.
6. Elmore S. // Toxicol. Pathol. - 2007. - N 35. - P. 495—516.
7. Harada C., Nakamura K., Namekata K. et al. // Am.J. Pathol. - 2006. - N 168. - P. 261-269.
8. Mattson M.P., Liu D. // Neuromolec. Medicine. - 2002. - Vol. 2, N 2. ó P. 215ó231.
9. Nijboer C.H., Heijnen C.J., Groenendaal F. et al. // Stroke. - 2008. - N 39. - P. 2129—2137.
10. Shawgo M.E., Shelton S.N., Robertson J.D. J. Biol. Chem. - 2008. P. 1074.
11. Sloviter R. // Trends Pharmacol. Sci. - 2002, - Vol. 23. ó P. 19ó24.
12. Yin W., Signore A.P., Imai M. et al. // Stroke. - 2008. - N 39. - P. 3057-3063.
Published
2019-10-29
How to Cite
Mamchur, V., KravchenkoК., Besedin, A., & Kulish, U. (2019). Neuroapoptosis and neuroprotection by NMDA-receptors antagonists. Farmatsevtychnyi Zhurnal, (4), 44-49. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/776
Section
Original Articles