Production of thick extract of marigold (Calendula officinalis L.) using different extracting conditions
Plant raw materials are the main source of biological active compounds despite the big progress of modern chemistry. Therefore, exploration and intensification related to process of extracting of active compounds from plant raw materials should be taken into special consideration.
Process of extracting (ejection) has very high importance in the modern pharmaceutical industry. By the method of extracting can be produced the main group of aggregated ((galenical) preparations – extracts and tinctures as well as neogalenicals, polyfraction extracts, ejections from fresh plants etc.
Process of extraction is the main method for not only for a production of aggregated preparations but also in technologies of extraction of individual pharmacologically active compounds from raw materials.
The aim of this research is production of thick extract of marigold under different extracting conditions using method of circulation maceration.
The samples of extracts with a different time of circulation of extracting agents trough lair of raw materials had been produced for determination of optimal conditions for extracting of marigold flowers by method of forced circulation of extraction agents.
70% ethanol was used as the extraction agent. Selection of samples was done during each stage of extracting process by the following scheme: infusing – circulation 60 min – circulation 120 min – circulation 180 min – circulation 240 min – circulation 300 min.
Dry residue of each sample was determined and exit of extracting compounds as well as exit of thick extract was calculated. Later, the samples of liquid extracts were stripped to forms of thick extracts. The following has been determined: the dry weight loss and sum of flavonoids in conversion to rutin and a dry compound. Identification of flavonoids and saponins was done as a qualitative test for each sample of thick extract.
Received data was presented in the form of diagrams which graphically reflect the process of extraction during different technological parameters.
Double-stage extraction is an optimum condition for extracting of flowers of marigold using method of the maceration with forcing circulation of extraction agents. This includes of maceration of row material during 120 minutes and circulation of fresh portion of extraction agents during 60 minutes. Duration of the process (excluding stages of preparation of row material and extraction agents) is 3 hours.
As a perspective of research is development of medical products in form of a cream which contains extract of marigold and can be used for prophylaxis and treatment of gynecological diseases.
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