Synthesis, physicochemical properties and acute toxicity 2-(4-(2-methoxyphienyl)-5-R-1,2,4-triazole-3-ylthio]-l-arylethanols

  • A.S. Gotsulya -
  • A.I. Panasenko -
  • Ye.G. Knysh -
  • Ye.S. Pruglo -
Keywords: 1,2,4-triazoi, arylethanols, synthesis, acute toxicity

Abstract

The new series of 2-[4-(2-methoxyphenyl)-5-R-1,2,4-triazole-3-ylthio]-l-arylethanols is synthesized, the structure confirmed by element analysis, IR-spectroscopy and their individuality — by the method of thin layer chromatography.

References

1. Georgievsky GV // Pharmacom. - 2006. - № 3. - P. 27—31.
2. Kozitsyna LA, KupletskayaNB. Application of UV, IR, NMR and MASS spectroscopy in organic chemistry / LA Kozitsyn. - 2nd ed., Remaking. and ext. - M .: Publisher. Mosk. Univ., 1979. - 236 p.
3. Mashkovsky M.D. Medicines / M.D. Mashkovsky. - M .: Medicine, 1986. - Vol. 1. - 621 p .; Vol. 2. - 575 p.
4. Panasenko OI Synthesis, transformation, physicochemical and biological properties of amino and thio derivatives of 1,2,4-triazole: dis .... Dr. Pharmac. Sciences / Panasenko OI - K., 2005. - 396 p.
5. Navin V. Patel, Imran N. Khan, Smita D. Rajani. // European Journal of Medicinal Chemistry. - 2010. - № 45. - P. 4293-4299.
Published
2019-10-29
How to Cite
Gotsulya, A., Panasenko, A., Knysh, Y., & Pruglo, Y. (2019). Synthesis, physicochemical properties and acute toxicity 2-(4-(2-methoxyphienyl)-5-R-1,2,4-triazole-3-ylthio]-l-arylethanols. Farmatsevtychnyi Zhurnal, (6), 32-35. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/743
Section
Original Articles

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