The rationale for the method of administration of decamethoxinum and lidocaine hydrochloride in the basis of drug films
It is known that the efficiency of the medicine depends on pharmaceutical factors, in particular on the technology of preparation. The choice of optimal technology preparation of a drug depends on such factors as the method of introducing active pharmaceutical ingredients in the drug. Therefore, in justifying the composition and technology of the new drug we studied the influence of excipients, the route of administration of active pharmaceutical ingredients in basis and manufactoring technology. The aim of our research was to study the introduction of decamethoxine and lidocaine hydrochloride in a basis of medicinal films, depending on the antimicrobial activity and further determination of their optimal concentrations.
We investigated antimicrobial activity modeling medicinal films samples containing decamethoxin in a concentration of from 4,412 to of 26.47 mcg/of cm2 at a constant concentration of lidocaine hydrochloride 176,5 mcg/of cm2.
Research of antimicrobial activity was conducted by the method of diffusion in an agar. Taking into account conducted microbiological researches we justified the method of introduction of decamethoxine and lidocaine hydrochloride in basis. Solution of decamethoxine and lidocaine hydrochloride are entered in the compound of the basis. It is set that at this method of introduction of API optimal concentration of decamethoxine is 8,824 mcg/of cm2 while the permanent concentration of lidocaine hydrochloride ‒ 176,5 mcg/of cm2. This model shows antimicrobial activity at the level of comperator drug ointment Miramistyn-Darnytsia.
The study of antimicrobial activity dependence in samples dependent on the method of introduction of decamethoxine showed that PEG 400 practically does not influence on antimicrobial activity. Therefore in future we choosed the method of introduction of decamethoxine and lidocaine hydrochloride as solutions. Thus active pharmaceutical ingredients are entered in mixture of polymers consisting of polivinil alcohol and polyacrylamide.
The prospect of this research is a rationale of technology of preparation of MF and study of their physical-mechanical and physical-chemical properties.
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