Quantitative analysis amoxicilline trihydrate in pharmaceutical preparation by the kinetic method

  • M.Ye. Blazheevskiy -
  • S.P. Karpova -
Keywords: spectrophotometry, amoxicilline, peroxomonosulfate acid

Abstract

The kinetic of couplied reactions of S-oxidation and perhydrolysis of amoxicilline with potassium peroxomonosulfate in alkaline medium is studied by light absorbance increase of a forming product at 296 nm. The procedure of the quantitative analysis of amoxicilline in capsules, pills and suspension by spectrophotometric-kinetic method is elaborated with using triple potassium Caro’s salt solution («Oxone») as a reagent. RSD ≤ 2,00 %. The results of analysis by the. method developed and standard pharmacopoeic techniques have been conformed well δ = (+0,1...—1,3) %.

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Published
2019-10-29
How to Cite
Blazheevskiy, M., & Karpova, S. (2019). Quantitative analysis amoxicilline trihydrate in pharmaceutical preparation by the kinetic method. Farmatsevtychnyi Zhurnal, (5), 55-61. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/729
Section
Original Articles