Synthesis, physical and chemical properties S-derivatives 5-geteril-4-(4-chlorobenzylamino)-1,2,4-triazole-3-thiols
Keywords:
1,2,4-triazol, salts, physical and chemical properties
Abstract
The salts of 2-(4-(4-chlorobenzylamino)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid and 2-(4-(4-chlorobenzylamino)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid with organic and inorganic bases is synthesized, the structure confirmed by element analysis,UF-, IR- spectroscopy, NMR- spectrometry, and their individuality - by the method of thin layer chromatography.
References
1. Knysh E.G. Synthesis, physicochemical and biological properties of N and S-substituted 1,2,4-triazoles: Dis. ... Dr. Pharmacist. Sciences. - H., 1987.- 350 p.
2. Panasenko OI Synthesis, transformations, physicochemical and biological properties of amino and thio derivatives of 1,2,4-triazole: diss. ... Dr. Pharmacist. Sciences. - K., 2005. - 396 p.
3. Kazitsyna L.A. Application of UV, IR, NMR and MASS spectroscopy in organic chemistry. - 2nd ed., Remaking. and ext. - M.: Publisher. Mosk. Univ., 1979. - 236 p.
4. Makovik YV Synthesis, physicochemical and biological properties of S-derivatives of 5- (3-pyridyl) - and 5- (3-pyridyl) -4-fashl-1,2,4-triazolyl-3-thione: diss. ... Cand. form of sciences. - K., 2008. - 223 p.
5. Gotsulya AS, Panasenko OI, Knysh EG // Medical chemistry. - 2007. - Т 9. - № 3. - P. 91-93.
6. Gotsulya AS, Panasenko OI, Knysh EG // Zaporozhye. honey. . - 2006. - No. 6 (39). - pp. 64-66.
7. Kaplaushenko AG, Lukyanchuk VD, Renzyak S.Ya. // Zaporozhye. honey. . - 2008. - № 4. - P. 127-130.
8. Kaplaushenko AG, Panasenko OI, Knish EG // Scientific-production professional journal "Herald". - 2007. - № 3. - P. 27-28.
9. Walsh T, Pappas P, Winston D and al // N Engl J Med 346 (4): 225-34.
10. Nickie D. Greer. / Posaconazole (Noxafil): a new triazole antifungal agent // Proc. (Bayl. Univ. Med. Cent.). 2007 April; 20 (2): 188-196.
2. Panasenko OI Synthesis, transformations, physicochemical and biological properties of amino and thio derivatives of 1,2,4-triazole: diss. ... Dr. Pharmacist. Sciences. - K., 2005. - 396 p.
3. Kazitsyna L.A. Application of UV, IR, NMR and MASS spectroscopy in organic chemistry. - 2nd ed., Remaking. and ext. - M.: Publisher. Mosk. Univ., 1979. - 236 p.
4. Makovik YV Synthesis, physicochemical and biological properties of S-derivatives of 5- (3-pyridyl) - and 5- (3-pyridyl) -4-fashl-1,2,4-triazolyl-3-thione: diss. ... Cand. form of sciences. - K., 2008. - 223 p.
5. Gotsulya AS, Panasenko OI, Knysh EG // Medical chemistry. - 2007. - Т 9. - № 3. - P. 91-93.
6. Gotsulya AS, Panasenko OI, Knysh EG // Zaporozhye. honey. . - 2006. - No. 6 (39). - pp. 64-66.
7. Kaplaushenko AG, Lukyanchuk VD, Renzyak S.Ya. // Zaporozhye. honey. . - 2008. - № 4. - P. 127-130.
8. Kaplaushenko AG, Panasenko OI, Knish EG // Scientific-production professional journal "Herald". - 2007. - № 3. - P. 27-28.
9. Walsh T, Pappas P, Winston D and al // N Engl J Med 346 (4): 225-34.
10. Nickie D. Greer. / Posaconazole (Noxafil): a new triazole antifungal agent // Proc. (Bayl. Univ. Med. Cent.). 2007 April; 20 (2): 188-196.
Published
2019-09-10
How to Cite
Safonov, A., Panasenko, A., & Knysh, Y. (2019). Synthesis, physical and chemical properties S-derivatives 5-geteril-4-(4-chlorobenzylamino)-1,2,4-triazole-3-thiols. Farmatsevtychnyi Zhurnal, (1), 49-53. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/709
Section
Original Articles
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