Determanation of the minimal concentration of sodium metabisulfite for stabilization of the infusion solution with glucose and sorbitol «Sorbicin»
Keywords:
stability, glucose, antioxidant, sodium metabisulfite, condition of sterilization, value pH, absorbancy, 5-oxymethylfurfurol, concentration of the stabilizer
Abstract
The research results of the effect of various concentrations of sodium metabisulfite on the stability of the analyze solution as after sterilization at 105 °C - 45 min. and 120 ^ - 12 min. as during storage. It was established that the optimum concentration of sodium metabisulfite is 0.03 %, at which polyelektrolitical infusion solution «Sorbidn» remain stable.
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of peritoneal dialysis / NI Gudz, RSKoritnyuk // Collection of scientific works of employees PL Thug. - K., 2001. - P. 1008-1012.
3. The processes of decomposition in polyionic solutions with energy substrates / RS Koritniuk, EE Borzunov, T.V. Torhov [and others] // Pharmaceutical Journal. - 1990. - № 1. - P. 31-35.
4. Tereshkina OI Investigation of glucose thermodestruction products in model solutions / OI Tereshkina, IVIsaeva // Pharmacy. - 1991. - № 6. - P. 24-28.
5. Torkhova TV Development of technologies of polyionic solutions with energy substrates for infusions: diss. Cand. formats. Sciences: 15.00.01. - K., 1989. - 156 p.
6. FatourosA .; Osterberg T .; Mikaelsson M. Recombinant Factor VIII SQ: Influence of Oxygen, Metal Ions, pH and Ionic Strength on its Stability in Aqueous Solution. Int. J. Pharm. 1997, 155, 121–131.
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Published
2019-07-01
How to Cite
Zdrajkovskaja, M., & Torkhova, T. V. (2019). Determanation of the minimal concentration of sodium metabisulfite for stabilization of the infusion solution with glucose and sorbitol «Sorbicin». Farmatsevtychnyi Zhurnal, (2), 75-80. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/682
Section
Original Articles
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