Quantitative analysis of sodium benzylpenicilline salt for preparation of solutions for injections

  • M.Ye. Blazheevskiy -
  • S.P. Karpova -
Keywords: spectrophotometry, benzylpenicilline, potasium peroxomonosulfate

Abstract

The kinetic of couplied reactions of S-oxidation and perhydrolysis of benzylpenicilline with potassium peroxomonosulfate in alkaline medium is studied by light absorbance increase of a forming product at 275 nm. The procedure of the quantitative analysis of sodium benzylpenicilline salt in powder by photometric-kinetic method is elaborated with using triple potassium Caro salt solution («Oxon») as a reagent. RSD < 2,0 %. The results of analysis by the method developed and standard pharmacopoeic tecniques have been conformed well (δ = +0,17%).

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Published
2019-07-01
How to Cite
Blazheevskiy, M., & Karpova, S. (2019). Quantitative analysis of sodium benzylpenicilline salt for preparation of solutions for injections. Farmatsevtychnyi Zhurnal, (2), 70-74. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/681
Section
Original Articles