Synthesis and antioxidant activity of derivatives 4.6-bis- (ethylamine)-2-atsyltiotryazyn-1,3,5

  • O.I. Barchyna -
  • I.V. Gerashchenko -
  • V.V. Sukhovyeyev -
  • O.S. Smolskyi -
  • A.M. Demchenko -
Keywords: nitrogen(II)oxide, oxidative stress, nitrosating stress; derivatives of 4.6-bis(ethylamine)-2-atsyltiotryazyn-1, 3,5; antioxidant; prooxidant

Abstract

This work considers the antioxidant action of the first synthesized 4.6-bis (ethylamine)-2- atsyltiotryazyniv-1,3,5.

Antiradical properties are investigated in vitro based on the effect of absorption of nitrogen(II)oxide radicals. It is found that depending on the nature of alkalizing components and R substitute in aromatic ring of s-triazine derivatives, they exhibit pro- or antioxidant effect, which exceeds ionol (E321).

These compounds may be used as initial substances in the development of drugs that operate in the conditions of oxidative stress.

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Published
2019-07-01
How to Cite
Barchyna, O., Gerashchenko, I., Sukhovyeyev, V., Smolskyi, O., & Demchenko, A. (2019). Synthesis and antioxidant activity of derivatives 4.6-bis- (ethylamine)-2-atsyltiotryazyn-1,3,5. Farmatsevtychnyi Zhurnal, (2), 56-61. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/678
Section
Original Articles