The methods of synthesis and pharmacologicaly properties of 4-bromo- and 4,6-dibromo-2-carboxysuccinalic acids anilides
Keywords:
synthesis, anthranilic, succinic acids, pharmacological activity
Abstract
Synthesis of 4-bromo- and 4,6-dibromo-2-carboxysuccinalic acids anilides has been carried out and their physico-chemical properties have been studied. The structure of the received substances is confirmed with the help IR-, PMR-spectral, element and chromatographic methods. According to classification by K.K. Sydorov, substances by intrastomach entering belong to low toxic compounds. It has been stated that the synthesized substances have antiinflammatory, analgetic, diuretic, fungistatic and bacteriostatic activity. A number of regularities of the «structure-activity» relationship have been determined.
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Published
2019-07-01
How to Cite
Kobzar, N., Isaev, S., Mamedova, D., Khrushova, O., Pavliy, O., Sergienko, O., & Brun, L. (2019). The methods of synthesis and pharmacologicaly properties of 4-bromo- and 4,6-dibromo-2-carboxysuccinalic acids anilides. Farmatsevtychnyi Zhurnal, (2), 49-55. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/677
Section
Original Articles
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