Synthesis, physicochemical properties and prediction of pharmacological activity of new 2-isopropyl-5,6-R-pyrimidine-4(3H)- one derivatives
Keywords:
synthesis, pyrimidine-4(3H)-one, alkylation, acetamides
Abstract
New 2-isopropyl,5,6-substituted derivatives of pyrimidine-4(3H)-one and their N-aryl-3-(2- isopropyl-5,6-R-pyrimidine-4(3H)-one)acetamides were synthesized. The structure of compounds was confirmed by methods of UV-, 'H, 13C NMR-spectroscopy and chromato-mass-spectrometry. The preliminary prognosis of biological activity of substances was carried out.
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Published
2019-07-01
How to Cite
Severina, A., Skupa, O., & Georgiyants, V. (2019). Synthesis, physicochemical properties and prediction of pharmacological activity of new 2-isopropyl-5,6-R-pyrimidine-4(3H)- one derivatives. Farmatsevtychnyi Zhurnal, (3), 54-59. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/653
Section
Original Articles
This work is licensed under a Creative Commons Attribution 4.0 International License.
