Synthesis and properties of derivatives of [1,3,4] thiadiasol [2,3-c] [1,2,4] triazine

  • A.M. Demchenko -
  • P.N. Kovbasa -
  • V.V. Suhoveev -
  • T.A. Buhtiarova -
  • O.Ye. Iadlovskyi -
Keywords: 4-amino-6-(tret-butyl)-3-methylthio-4,5-dihydro-1,2,4-riazine-5-on, 7-sulfanyl-3- (tret-butyl)-4-H-[1,3,4]thiadiazol-[2,3-c][1,2,4] triazine-4-on; analgesic and anti-inflammatory activity; α-hloratsetamids; halohenketons; benzylhalohenids

Abstract

The 7-sulfanyl-3-(tert-butyl) - 4-N-[1,3,4] tiadiazolo-[2,3-c] [1,2,4]-triazine-4-on is obtained by condensation of 4-amino-6-(tret-butyl)-3-methylthio-4, 5-dihydro-1, 2,4-triazine-5-on with disulfide of carbon. Several derivatives which exhibit high analgesic and anti-inflammatory activity are synthesized by means of reactions of the latter with alkylating reagents.

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Published
2019-07-01
How to Cite
Demchenko, A., Kovbasa, P., Suhoveev, V., Buhtiarova, T., & Iadlovskyi, O. (2019). Synthesis and properties of derivatives of [1,3,4] thiadiasol [2,3-c] [1,2,4] triazine. Farmatsevtychnyi Zhurnal, (3), 33-37. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/649
Section
Original Articles