Influence of frigoprotektors on the renal excretory function of mice after acute total cooling
Keywords:
cold disease, frigoprotektors, renal excretory function
Abstract
It is established that in the regenerative period after acute total cooling at mice have a tendency to the increase of diuresis and renal function is disturbed concentration. The most significant influence on a renal function had a glucosamine hydrochloride in a dose 25 mg/ kg and bemitil in a dose 50 mg/kg in contrast to acetylsalicylic acid 25 mg/kg. At the use of lipin in a dose 734 mg/kg tended to nrestore of concentration of renal function compared with animal of the control diseases.
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9. Pat. 52379 for utility model, Ukraine, МПК2 А61К 36/00, А61Р 17/02 (2006.01). Application of lipine as a means of frigoprotective action / Domar N. A., Strigol S.Yu., Piminov O. F., Bondariev E.V .; Applicant and patent holder National Pharmaceutical University. - № u201001836; stated. February 19, 2010; published 25.08.2010. - Bül No. 16
10. Increase in life expectancy of mice during acute cooling under the action of a preparation isolated from Laminaria sacchara / Drozd Yu.V., Bondarenko S.V., Yasnetsov V.V. and others // Biol. experiment biol. and honey - 1991. - Vol. 111, No. 4. - P. 383-384.
11. Shapovalov K.G. Cold trauma as a cause of persistent changes in the microcirculatory channel state / K.G.Shapovalov, V.A.Sizonenko // Surgery. - 2009. - №2, pp. 28-31.
12. Strigol S.Yu. Modulation of pharmacological effects under different salt regimes. - Kharkiv: Avista-VLT, 2007. - 360 s.
13. Ambiances termiques: travailler au froid / Ganem Y., Pomian Jl., Laborde L. et al. // Documents to the Medecin du Travail. - 2006 - Vol. 107, № 3. - P. 279-295.
14. Atkinson R.T., Turner G. B., Herity N.A. Electrocardiographic abnormalities in an elderly woman // Postgrad. Med.J. - 1999. - Vol. 75. - P. 505-507.
15. Jia J., Pollock M., Jia J. Cold injury to nerves is not due to ischaemia alone // Brain.
- 1998. - Vol. 121, №1 - P. 989-1001.
16. MalletM.L. Pathophysiology of accidental hypothermia // Q.J. Med. - 2002. - Vol. 95, No. 1. - P. 775-785.
Published
2019-03-18
How to Cite
Domar, N., Bondarev, E., Shtrygol, S., & Piminov, A. (2019). Influence of frigoprotektors on the renal excretory function of mice after acute total cooling. Farmatsevtychnyi Zhurnal, (6), 49-55. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/568
Section
Original Articles
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