Elaboration and validation of analytical method of sulphamethazine spektrophotometric determination in medicine "Mastisanum-а-forte"

  • М.Ya. Boiko -
  • Т.Ya. Vrublevska -
  • О.Ya. Korkuna -
  • I.Ya. Kotsiumbas -
  • G.Yu. Teslyar -
  • О.G. Smalyuh -
Keywords: Mastisanum-А-Forte, sulphamethazine, Tropaeolin O, spectrophotometry, quantitative determination, validation parameters

Abstract

On the basis of absorbance measuring of the coloured azocoupling reaction products of diazotized sulphamethazine with monoazo dye tropaeolin O, the analytical method of sulphamethazine spectrophotometric determination in veterinary preparation (suspension) "Mastisanum-А-Forte" has been elaborated. Data of conducted validating studied with the use of criterion admissibility for the content limits В = ±5,0%, confirmed the specificity, robustness linearity, accuracy, precision, intermediate precision and reproducibility of proposed method in the range of its application.

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Published
2019-03-18
How to Cite
BoikoМ., VrublevskaТ., KorkunaО., Kotsiumbas, I., Teslyar, G., & SmalyuhО. (2019). Elaboration and validation of analytical method of sulphamethazine spektrophotometric determination in medicine "Mastisanum-а-forte". Farmatsevtychnyi Zhurnal, (2), 50-59. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/530
Section
Original Articles