Investigation of ocmotic activity of the combination of hydrophilic, non-aqueous solvents for drug development for the treatment of wound healing (I phase)
The experimental researches were performed regarding to the effects of hydrophilic non-aqueous solvents and their concentrations to the osmotic properties of emulsion systems – modeling samples with PEO-400, propylene glycol, glycerin in the various concentrations. The optimal concentration of hydrophilic non-aqueous solvents (PEO-400 – 10% and glycerin –5% ), which determine the specific osmotic activity of mild medicines was found out by in vitro method.
2. Privolnev V.V., Karakulina E.V. Basic principles of local treatment of wounds and wound infection // Klin. microbial antimicrobial chemotherapy. - 2011. - T. 13, No. 3. - P. 214-222.
3. Zmushko E.I., Belozerov E.S. Medicinal complications. - St. Petersburg: Peter, 2001. - 448 p.
4. Pharmaceutical care: A course of lectures for pharmacists and family doctors, Ed. V. P. Chernykh, I. A. Zupanets, V. A. Ksenko. - Kharkiv: Megapolis, 2003. - 608 p.
5. Maisch T. Anti-microbial photodynamic therapy: useful in the future // Lasers in Medical Science. - 2007. - V. 22, N 2. - P. 83-91.
6. Gladuk, Ye.V. Study of osmotic activity of first-order emulsions // Bulletin of pharmacy. - 2002. - No. 4 (32). - P. 38-41.
7. Davtyan L. L. Study of Osmotic Properties of Model Foundations Depending on the Carrier // Pharmac. journ - 2003. - No. 3. - P. 74-77.
8. Joglo FA Non-aqueous solvents. Characteristics, properties and application in the technology of finished dosage forms. - Lviv: Poster, 2002. - 80 p.
This work is licensed under a Creative Commons Attribution 4.0 International License.