Choice of excipients to develop composition tablets with esomeprazole
Researched the physic-chemical properties of the active ingredient esomeprazole. To improve technological performance tableting mass at different stages of the process (making granules for tableting mass, pressing tablets) are selected and introduced excipients. Studies of their functional purpose, investigated and confirmed compatibility support and active substances and intermediates studied technological characteristics from the point of view of their pharmacological characteristics of the technological requirements of the State Pharmacopoeia of Ukraine. For the development of technology and tablets esomeprazole-cores used wet granulation method. As a result of technological and biopharmaceutical studies selected quality of tablets esomeprazole-cores.
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