Study osmotic properties vaginal suppositories combined exposure with anti-microbial and anti-inflammatory activity
A study to determine the osmotic activity suppository bases (hydrophilic and hydrophobic) and selecting the most appropriate samples for further pharmaceutical development suppositories. Selected samples meet medical and biological requirements that apply to drugs with local action. It is set experimental researches, that osmotic activity of hydrophilic bases in two times exceeds activity of hydrophobic bases. On osmotic activity can hydrophobic bases be placed in a next sequence – 6>2>5>1, and hydrophilic – 3>10>8>9>4>7.
On the basis of experimental researches by us grounded choice of next hydrophobic model standards of suppository bases - 1, 5 and 6. The study of index of osmotic activity of model standards enables to make decision in relation to subsequent addition superficially active substances in the complement of the probed bases.
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