Establishment the period of validity of soft drug for the treatment of wounds in the second phase of process

  • V. Rudenko National Medical Academy of Post-Graduate Education named after P. L. Shupyk, Kyiv
Keywords: use-by, stability, specification date

Abstract

Investigations to establish the shelf-life of soft drug in the form of an ointment to treat wounds in the II phase of wound healing. Studies carried out after 27 months storage at temperature 15-25 °C, 2-8 °C, 8-15 °C. Stability studies ointment in different storage conditions conducted on the following parameters: description, identification, homogeneity, pH, particle size, quantification, antimicrobial activity and microbiological purity. The correspondence of proven performance of soft drug to set the indicators for specification characteristics.

References

1. Bondarenko OV, Kazarinov NA, Pashneva RA, Rapshtina MV Development of composition and choice of rational drug form of combined preparation on the basis of vegetative raw materials // Akto. pharmacist's question. honey. science and practice. Zb sciences Articles, Vip. ХV, Т. 2,  Zaporozhye: View. ZSMU, 2006. - P. 306-311.
2. Gladyshev VV, Fedorchuk V.V., Baranova G.I. and others. Development of a gel with a new antiseptic drug polyhexamethylene guanidine phosphate // Vysn. pharmacy - 2002. - No. 2 (30). - P. 58-59.
3. State Pharmacopoeia of Ukraine., Kind. I / C edit Georgievsky V.P. -Harkov: RIREG. - 2001. - 531 p.
4. State Pharmacopoeia of Ukraine, Kind. And, Dop. 1 / Under. edit Georgievsky V.P. - Kharkiv: RIREG. - 2004 - 492 pp.
5. State Pharmacopoeia of Ukraine, Kind. And, Dop. 2 / under. edit Grizodub O. I. - Kharkiv: RIREG. - 2008 - 617 pp.
6. Kondratyuk NA, Laryanovskaya Yu.B., Kutsenko T.O. Investigation of the effect of new combined suppositories on the morphological state of the rectum of rats at the experimental proctitis // Klin. pharmacy. - 2009. - No. 3. - P. 39-42.
Published
2019-02-12
How to Cite
Rudenko, V. (2019). Establishment the period of validity of soft drug for the treatment of wounds in the second phase of process. Farmatsevtychnyi Zhurnal, (3), 46-51. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/401
Section
Pharmaceutical technology