The influence of temperature condition for technology ointment

  • V. Rudenko P. L. Shupik National Academy of Post-Graduate Education, Kyiv
Keywords: pharmaceutical active ingredient, soft drugs, therapeutic efficacy, pharmaceutical factors, temperature


Today in dermatological practice all over the world are widely used soft drugs in the form of an ointment. This is due to the following advantages of this formulation: the relative ease and safety of use, ability to use both local and resorptive action, ensuring a high concentration of active ingredients in the application, the possibility of prolonged action, combination in the form of one-pharmaceutical active ingredients from different pharmacological groups . The development of new domestic drug is in the form of topical ointments, as the number of dermatological diseases is constantly increasing.

The aim of this study was to investigate the microbiological activity of samples of emulsion ointments containing clotrimazole. Of these studies preceded the study of the dependence of release of clotrimazole from the liquid which was suspended, and the study of particle size depending on the production method of ointment.

Research materials were samples of emulsion ointment containing clotrimazole, made by three different methods. In the work we used microbiological and pharmacological technological methods.

The study was the establishment of that auxiliaries which were part of the ointment promotes the release of clotrimazole with an ointment base. As is known, one of the pharmaceutical factors that directly affect the therapeutic effectiveness of the drug is the technology for their manufacture. Considering this important factor we have produced pilot models ointments on different technology and studied their microbiological activity.

Microbiological analysis showed that the greatest area of growth retardation organisms we see in the model sample ointment was prepared by hot / hot / cold.

Thus conducted comprehensive studies allow us to select a sample of ointment made by hot / hot / cold for further investigations.


1. Biopharmacy: Textbook. for the pharmacist. high schools and fac. / AI Tikhonov, TG Yarnykh, IA Zupanets and others. Ed. AI Tikhonova. - Kharkov: Publishing house of NFUU; Golden Pages, 2003. - 238 p.
2. D. I. Dmitrievsky, V. D. Rybachuk, V. M. Khomenko and others. Auxiliary substances in medicine technology: influence on technological, consumer, economic characteristics and therapeutic effectiveness: teaching. manual for studio higher pharmacy tutor shut up / Ed. I. M. Perceva. - Kharkiv: Golden Pages, 2010. - 600 p.
3. Pharmaceutical technology. Technology of dosage forms. "Uch. For college students studying Institution / Ed. I. I. Krasnyuk, G. V. Mikhailova. 2 ed. - M., 2006 - 448 p.
4. Gupta G. D., Gaud R. S. Practical Microbiology. 3rd ed. - Pune: Nirali Prakashan, 2004. - P. 40-44.
5. Sinko P. J. Physical Pharmacy and Pharmaceutical Sciences. 5th ed. - Lippincott W Philadelphia, 2006. - P. 301-326.
6. Patrick J. Crowley, Luigi G. Martini. Excipients for Pharmaceutical Dosage Forms / Encyclopedia of Pharmaceutical Technology. Ed. J. Swarbrick, J. C. Boylan. 3rd ed. - N.Y.: Marcel Dekker Inc., 2002. - P. 1151-1163.
How to Cite
Rudenko, V. (2019). The influence of temperature condition for technology ointment. Farmatsevtychnyi Zhurnal, (4), 47-51. Retrieved from
Pharmaceutical technology