Effect of tablet size on trimetazidine dihydrochloride and caffeine in vitro release from matrix tablets with different matrix formers
Oral matrix tablet with extended release of active pharmaceutical ingredient (API) is popular dosage forms that allow to achieve desirable in vitro drug release and correspondent level of therapeutic concentration in vivo. That’s why, the research of factors that can to influence on in vitro drug release is an actual task.
Effect of tablet size increasing with simultaneous tablet mass increasing on in vitro release of trimetazidine dihydrochloride and caffeine from matrix tablets obtained by direct compression method was discovered.
It was found that initial tablet surface area to volume ratio (S/V) was decreasing with increasing of tablet size.
It was proved that diffusion release of TMZ∙2HCl and caffeine decreased with decreasing of initial tablet S/V and was close to linear dependence on initial tablet S/V according to Lapidus and Lordi equation independently of matrix former and API solubility.
Results of this experiment are the basis of further investigation of matrix type effect on API release from matrix tablets.
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