Synthesis, structure and research of pharmacological activity of methyl esters of 4,5-dymethoxy-N-phenylanthranilic acids

  • A. O. Devjatkina National University of Pharmasy, Kharkiv
  • S. G. Isaev National University of Pharmasy, Kharkiv
  • O. V. Kiz National University of Pharmasy, Kharkiv
  • G. P. Zhegynova National University of Pharmasy, Kharkiv
Keywords: synthes, methyl esters N-phenylanthranilic acids, pharmacological activity

Abstract

The derivatives of N-phenylanthranilic acid is widely used in the medical and chemical industries. Based on the urgency of the search for new biologically active substances derivatives of anthranilic acids work has been done on the development of methods of synthesis and experimental studies of the methyl esters of 4,5-dymethoxy-N-phenilantharnilic acids.

The synthesis was carried out at the Department of Medical Chemistry The National University of Pharmacy. The biological screening of new compounds conducted at the Department of Microbiology, Virology and Immunology The National University of Pharmacy.

The synthesis of methyl esters of 4,5-dymethoxy-N-phenylanthranilic acids has been carried out. The composition of 9 synthesized compounds was proved by the data of element analysis and their IR-spectra. The purity was controlled by the method of thin-layer chromatography. It was established, that the synthesized substances have anti-inflammatory, analgetic, diuretic, antidiuretic, bacteriostatic and antifungal activity. According to classification by K.K. Sydorov, synthesized compounds at their intrastomach entering belong to low toxic compounds (DL50=1 500–2 000 mg/kg). A number of regularities of the «structure–activity–toxicity» relationship have been determined.

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Published
2019-02-12
How to Cite
Devjatkina, A. O., Isaev, S. G., Kiz, O. V., & Zhegynova, G. P. (2019). Synthesis, structure and research of pharmacological activity of methyl esters of 4,5-dymethoxy-N-phenylanthranilic acids. Farmatsevtychnyi Zhurnal, (6), 53-61. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/363
Section
Original Articles