Study of qualitative and quantitative composition of lipophilic compounds in the extract of pumpkin pulp (Cucurbita pepo L.)

  • L. I. Vyshnevskaya National University of Pharmacy, Kharkiv
  • E. A. Degtyaryovа National University of Pharmacy, Kharkiv
  • Y. I. Bysaha Uzhhorodskyе National University
Keywords: waste product, herbal raw material, pumpkin, pulp, chemical composition, lipophilic substances

Abstract

The extracts of medicinal plants included into the composition of many drugs as active substances. Due to the presence in plants of different classes of biologically active substances with different pharmacological effects, it is possible to usethem for the treatment and prevention of many diseases. One of such plantsis pumpkin (Cucurbita pepo L.), which belongs to the family Cucurbitaceae.

The aim of our work was investigation and studying at the chemical composition of biologically active compounds of the lipophilic extracts of pumpkin by the method of chromatography-mass spectrometry.

The object of the study was lipophilic extract of pumpkin pulp meal which had been prepared by using the hexane as solvent (1:6).

The cake of pumpkin pulp from the (Cucurbita pepo L. and Cucurbita moschata (Duch) Poir.) after juice production in 2013 was the raw material for producing at the extract.

In the lipophilic extract of pumpkin pulp 37 compounds. Of the seare present 10 fattyacids, of which 7 – saturated (lauric, caproic, myristic, palmitic, pentadecanoic, heptadecanoic, behenic), 2 – polyunsaturated (linoleicand, linolenic), 1 – monounsaturated (oleic). The greatest number of identified palmitic (6 232.6 mg/kg) and oleic (4 158 mg/kg) acids. It was also β-tocopherol (vitamin E) in an amount of 1 102.3 mg/kg and squalene (210.5 mg/kg) were identified.

The development of drugs for the prevention and treatment of various diseases is perspective due to the presence and big number of identified compounds in the lipophilic extract of pumpkin pulp.

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Published
2019-02-12
How to Cite
Vyshnevskaya, L. I., DegtyaryovаE. A., & Bysaha, Y. I. (2019). Study of qualitative and quantitative composition of lipophilic compounds in the extract of pumpkin pulp (Cucurbita pepo L.). Farmatsevtychnyi Zhurnal, (4), 47-52. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/348
Section
Pharmacological, phytochemical research