Synthesis of row ylidenederivatives 4-amіno-3-(morfolіno-methylen)-4H-1,2,4-trіazol-5-thіol

  • R. О. Shcherbyna Zaporizhzhіa State Medical University
  • O. I. Panasenko Zaporizhzhіa State Medical University
  • Ye. H. Knysh Zaporizhzhіa State Medical University
Keywords: organic synthesis ylidenederivatives, 1,2,4-triazole

Abstract

Synthetic transformations of heterocyclic systems in order to develop biologically active agents have become the fundamental basis of actively progressing scientific direction of thin organic synthesis and medicinal chemistry. In this context, a highly practical and theoretical interest are represents the derivatives of 4-amino-1,2,4-triazole-5-thiol since they shows anti-inflammatory, antipyretic, analgesic, antimicrobial and anti-TB activities. Therefore, the synthesis new row of ylidenederivatives of 4-amino-3-(morpholinomethylene)-4H-1,2,4-triazole-5-thiol is very important.

The purpose of this research is synthesis of new row ylidenederivatives 4-amino-3-(morpholinomethylene)-4H-1,2,4-triazole-5-thiol, and confirmation of their structure.

Study of the physicochemical properties of the synthesized compounds carried out according to the State Pharmacopoeia of Ukraine. Melting points were determined by open capillary method on instrument OptiMelt MPA100. The elemental composition of the synthesized compounds were established on the analyzer Elementar Vario L cube (CHNS) . 1H NMR spectra of the compounds were filmed by using a spectrometer Varian Mercury VX-200. Chromatography-mass spectral studies were carried out on gas-liquid chromatography Agilent 1260 Infinity HPLC with mass spectrometer Agilent 6120.

As the result of research new 23 compounds are synthesized namely potassium 2-(2-morpholinoacetyl)hydrazinecarbodithioate, 4-amino-3-(morpholinomethylene)-4H-1,2,4-triazole-5-thiol and 4-(R-ylidenamino)-3-(morpholinomethylene)-4H-1,2,4-triazole-5-thiols. The structure of the synthesized compounds were confirmed in all cases by modern instrumental analysis methods (1H NMR-spectroscopy, chromatography-mass spectrometry and element analysis), and the obtained compounds may further be used in biological research.

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Published
2019-02-12
How to Cite
ShcherbynaR. О., Panasenko, O. I., & Knysh, Y. H. (2019). Synthesis of row ylidenederivatives 4-amіno-3-(morfolіno-methylen)-4H-1,2,4-trіazol-5-thіol. Farmatsevtychnyi Zhurnal, (5), 63-69. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/333
Section
Synthesis and analysis of biologically active compounds

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