Experimental study of antimicrobial activity of gel based on PHDP and its combinations with azelaic acid and benzoyl peroxide

  • S. G. Bobro National University of Pharmacy, Kharkiv
  • A. I. Tikhonov National University of Pharmacy, Kharkiv
Keywords: diseases of the skin, acne, propolis, gel, acid azelaic, antimicrobial activity

Abstract

The creation of combined medicines for the treatment of dermatological diseases based on the substances of natural origin, in particular phenol-hydrophobic drug propolis with reduced content of benzoyl peroxide and azelaic acid, is highly relevant, as the active substances in this combination provide purposefully effective pharmacological action with minimal side effect sat the appropriate level.

The aim of this work was the experimental study of antimicrobial activity of a medicinal product in the form of a gel intended for the treatment of acne which we are working up.

The object of the study were the model samples of new ex tempore compositions of soft medicinal forms – gels containing the active pharmaceutical ingredients – phenol-hydrophobic drug propolis, azelaic acid and benzoyl peroxide. We used the traditional method «diffusion in to agar» («the wells method»).

References

1. Phenolic hydrophobic propolis (PHGP) - PP # UA / 4505/01, Order of the Ministry of Health of Ukraine No. 337 dated 06/07/2011.
2. Tikhonov O.I., Yarnykh T.G., Chernykh V.P. and others. Theory and Practice of Drug Propolis Production / Ed. acad. OI Tikhonova. - Kharkiv: Basis, 1998. - 384 p.
3. Tichonov A. I., Jarnych T. G., Czernych W. P. et al. Theory of Practicum for Propulsion Preparations / Pod Editor of the Academy AI Tichonov. Editor of the Polish Academy of Sciences prof. dr hab. Bogdan Kedzia. - Krakow: Mark "Mark", 2005 - 274 c.
4. Ozolin M., Eady E. A., Avery A. J. et al. Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomized controlled trial // Lancet. - 2004. - No. 364. - P. 2188-2195.
5. Harper J. C. Benzoyl Peroxide Development, Pharmacology, Formulation and Clinical Use in Topical Fixed-Combinations // J. Drugs Dermatol. - 2010. - V. 9, N 5. - P. 482-487.
6. Sagransky M., Yentzer B. A., Feldman S. R. Benzoyl peroxide: A review of its current use in the treatment of acne vulgaris // Expert Opin Pharmacother. - 2009. - V. 10, N 16. - P. 2555-2562.
7. Tanghetti E.A., Popp K.F. A current review of topical benzoyl peroxides: new perspectives on formulation and utilization // Dermatol. Clin - 2009. - V. 27, N 1. - P. 17-24.
8. Worret W. I., Fluhr J. W. Acne treatment with topical benzoyl peroxides, antibiotics and azelaic acid // J. Dtsch. Dermatol Ges - 2006. - V 4, N 4. - P. 293-300.
9. Fluhr J. W., Degitz K. Antibiotics, azelaic acid and benzoyl peroxide in topical acne therapy // J. Dtsch. Dermatol Ges - 2010. - V. 8, Suppl 1. - S. 24-30.
10. Gollnick Harald PM, Graupe Klaus, Zaumseil Rolf-Peter. Azelaic acid 15% gel in the treatment of acne vulgaris. Combined results of two double-blind clinical comparative studies // JDDG. - 2004 - V 2, N 10. - pp. 841-847.
11. Bobro S.G., Tikhonov O.I. Grounding the choice of basis for the preparation of a hydrophilic gel from the FGPP // Actual questions of scientific and practical cosmetology 2014: Mat. Allukr science-practice conf. from international Participation (April 17-18, 2014, Zaporozhye city). - View at ZSMU, 2014. - P. 47-48.
12. Method. recommendations "Study of the specific activity of antimicrobial drugs". - K., 2004. - 38 p.
13. Method. instructions of the Ministry of Health of Ukraine "Determination of sensitivity of microorganisms to antibacterial drugs". - K., 2007, No. MB 9.9.5-143-2007.
14. Order of the Ministry of Health of Ukraine No. 167 of 05.04.2007 "Determination of the Sensitivity of Microorganisms to Antibacterial Drugs".
15. Parker W. E., Witnauer L. P., Swern D. Peroxides IV. Aliphatic Diperacids. // J. Amer. Chem Soc - 1957 - V. 79. - P. 1929-1931.
Published
2019-02-12
How to Cite
Bobro, S. G., & Tikhonov, A. I. (2019). Experimental study of antimicrobial activity of gel based on PHDP and its combinations with azelaic acid and benzoyl peroxide. Farmatsevtychnyi Zhurnal, (5), 36-40. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/329
Section
Pharmaceutical technology