Study of anti-ulcer activity of quince leaves extracts

  • E. V. Kuznietsova State Institution «Institute of Pharmacology and Toxicology of National Medical Academy of Sciense of Ukraine», Kyiv
  • T. V. Dzhan State Institution «Institute of Pharmacology and Toxicology of National Medical Academy of Sciense of Ukraine», Kyiv
  • S. V. Klimenko Gryshko National Botanic Garden, Kyiv
Keywords: quince, sorts, leaves, procyanidins, hydroxycinnamic acids, antiulcer activity


The leaves of fruit plants are promising raw material for the production of biologically active additives with different pharmacological activity.

The results of the anti-ulcer activity study of quince and quince-apple hybrids leaves extracts for sorts of the M.M. Grishko National Botanical Garden selection are given in this article. The leaves of quince are characterized by a high content of hydroxycinnamic acids, flavonoids and procyanidins.

Study of anti-ulcer activity of the leaves aqueous extracts was performed on a model of alcohol-prednisolone gastric lesions in rats. Assessment of the anti-ulcer activity intensity was performed in terms of the ulcers formation intensity in the gastric mucosa: the percentage of animals with ulcers in the group and ulcerative index, making it possible to calculate the antiulcer activity (AUA). The study found that the administration of leaves extracts of quince different varieties helped to reduce the degree of ulceration in different ways. Extract of quince leaves of sort Academic had the most activity – AUA 21,3%. Only one rat had small erosion in a gastric mucosa among 5 animals per group. Extracts of quince-apple hybrid leaves of 4 form  and quince leaves of sort Maria had less activity more the quince leaves extract of sort Academic – AUA 17,0% and 14,2%, respectively. Determination of procyanidins and hydroxycinnamic acids in leaves quince and its hybrids showed that AUA depends of procyanidin content in the protein-polysaccharide complex.

The results of studies of the polyphenol compounds extraction were shown that the optimal degree of raw materials grinding is 1–1.5 mm, the ratio of raw material and extraction agent is 1:15, the extraction time is 60 min.


1. State Pharmacopoeia of Ukraine / State Enterprise "Scientific Expert Pharmacopoeia Center". 1st kind. - Kharkiv: RIREG, 2001. - Ex. 2. - 2008. - P. 128.
2. Jan T. V. Investigation of the content of phenolic compounds in the leaf of quince (Cydonia oblonga L.) / Actual problems of modern medicine: Mat. ІІІ (64) International Cong // Ukr sci. honey youth magazine - 2010. - No. 4. - P. 503.
3. Preclinical research of drugs: Method. rivers / Ed. Corr. AMS of Ukraine O. V. Stefanova. - K .: Avicenna, 2001. - 528 p.
4. Jan T. V., Konovalova O.Yu., Shuraeva T.K. and others. Investigation of the accumulation of biologically active compounds in the leaves of quince ordinary Cydonia oblonga L. // Farmac. magazine - 2010. - No. 6. - P. 97-100.
5. Jan T.V., Konovalova O.Yu., Kutsenko T.O., Klymenko S.V. Investigation of anti-ulcerative effects of Ivy Cydonia oblonga L. and chanomeles Chaenomeles Lindl. // Sb. sciences works of co-workers. NMAPO named after P. L. Shupyk. - K., 2011. - P. 474-478.
6. Klymenko SV Iva ordinary. - K .: Science. opinion, 1993. - 286 pp.
7. Oliveira A. P., Silva B. M. Marmelo (Cydonia oblonga Miller): Fonts of the compost biologicamente activos // Revista da Faculdade de Ciências da Saúde. Porto - 2007. - N 4. - P. 76-86.
How to Cite
Kuznietsova, E. V., Dzhan, T. V., & Klimenko, S. V. (2019). Study of anti-ulcer activity of quince leaves extracts. Farmatsevtychnyi Zhurnal, (1), 81-85. Retrieved from