Synthesis, structure and pharmacological properties of 9-(R-benzyliden)hydrazino-5-nitroacridines

  • S. G. Isaev National University of Pharmacy, Kharkiv
  • H. O. Yeriomina National University of Pharmacy, Kharkiv
  • S. G. Taran National University of Pharmacy, Kharkiv
  • H. Yu. Shevelyova National University of Pharmacy, Kharkiv
Keywords: synthesis, 9-(R-benzyliden)hydrazino-5-nitroacridines, pharmacological activity

Abstract

Annual publications of various properties of derivatives of acridin in various areas of science and equipment testify to expediency of synthesis of new derivatives dibenzpyridine.

Synthesis of 5-nitro-9-(R-benzyliden)hydrazinoacridines is for this purpose carried out, their physical and chemical and biological properties were studied. Structure of synthesized compounds has been proved by the date of element analysis, IR-, NMR-spectroscopy. The purity has been controlled by the method of the thin-layer chromatography.

The computer prognosis of possible types of pharmacological activity is carried out of 10 first synthesized connections in the row of 5-nitro-9-(R-benzyliden)hydrazinoacridines. By means of biological researches it was established that the synthesized compounds have antimicrobial, antifungal, anti-inflammatory, diuretic, antidiuretic and analgesic activity. A number of regularities of the «structure – biological activity – toxicity».

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Published
2019-02-12
How to Cite
Isaev, S. G., Yeriomina, H. O., Taran, S. G., & Shevelyova, H. Y. (2019). Synthesis, structure and pharmacological properties of 9-(R-benzyliden)hydrazino-5-nitroacridines. Farmatsevtychnyi Zhurnal, (1), 66-73. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/319
Section
Original Articles