Preclinical study of the gel for gingivitis treatment specific activity

  • V. S. Portyanko National University of Pharmacy, Kharkiv
  • Sv. N. Kovalenko National University of Pharmacy, Kharkiv
  • L. N. Maloshtan National University of Pharmacy, Kharkiv
Keywords: aminocaproic acid, gel, gingivit, specific activity, triclosan, spike oil

Abstract

Gingivitis is gum inflammation, which is characterized by puffiness and bleeding gums. Modern medicament for this rife disease treatment should pronounce anti-inflammatory, antibacterial and hemostatic activity.

The aim of the research was to study preclinical pharmacological action of the new dental gel based on triclosan, spike oil and aminocaproic acid.

The study included examining the effect on vascular tissue permeability to detect activity of the new gel formed drug for gingivitis pharmacotherapy.

The experiment found that the gel samples with triclosan at 0.5 cm/1 animal showed moderate vasofirming activity.

Research of the gel with the triclosan, spike oil and aminocaproic acid anti-inflammatory action were performed on karagenin edema model. Experimental proved that the developed gel has a mild anti-inflammatory effect and reduces the amount of edema by 27.8%.

In order to determine the influence of the developed gel exhibits pronounced hemostatic activity.

Therefore, the results of preclinical studies confirmed pronounced pharmacological effect and efficiency of the developed dental gel that can be recommended for further research and implementation in the medical and dental practices.

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Published
2019-02-12
How to Cite
Portyanko, V. S., Kovalenko, S. N., & Maloshtan, L. N. (2019). Preclinical study of the gel for gingivitis treatment specific activity. Farmatsevtychnyi Zhurnal, (3), 83-87. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/292
Section
General and Clinical Pharmacology