Development of the technology of cream for diabetic foot
Diabetes mellitus is one of the most difficult problems of our time. Aggravating factors in the course of the disease are numerous complications that lead to disability and early mortality. One of the most dangerous complications of diabetes mellitus considered to be diabetic foot syndrome. Existing tools for diabetes therapy available in the market of Ukraine does not provide an optimal impact on all parts of the pathogenesis of this syndrome. Products for preventing diabetic foot syndrome ulcer forms presented by foreign cosmetic products.
The aim of our work was to develop a rational technology of cream for use in diabetic foot with a stepwise description and considering temperature, mixing regime, the duration of each stage, etc.
Samples with α-lipoic acid, urea and tea tree oil were selected as objects for cream technology research. Based on thermogravimetric analysis and structural-mechanical studies substantiated the optimum temperature for incorporating active components of developed cream. Also during technological research, we have developed technology of cream based on α-lipoic acid and urea for use in diabetic foot and composed technological scheme of production.
2. Ziegler D., Nowak H., Kempler P. et al. Treatment of symptomatic diabetic polyneuropathy with an antioxidant alpha lipoic acid: a meta-analysis // Diabetic Medicine. - 2004. - N 21. - P. 114-121.
3. Gudrun Lang, Gerhard Buchbauer. A review of recent research results (2008-2010) for essential oils as antimicrobials and antifungals // Flavor and Fragrance J. -2012. - V. 27, Issue 1. - P. 13-39.
4. State Pharmacopoeia of Ukraine / State. the "Scientific and expert center". - The first view. - Kharkiv: RIREG, 2001. - 556 pp.
5. Creams cosmetic. General specifications: DSTU 4765: 2007 (Effective from 01/01/2009). - K .: Derzhspozhyvstandart of Ukraine, 2008. - 7 p.
6. Nikitina MV, Baranova I. I. Development of technology of cream-gel for the treatment of acne / Mater. science-practice conf. "Pharmacy of Ukraine. Looking to the future ", September 17, 2010 - Kharkiv, 2010. - P. 530.
7. Peppers I. M., Dmitrievsky D. I., Rybachuk V. D. and others. Auxiliary substances in medicine technology: influence on technological, consumer, economic characteristics and therapeutic effectiveness: Teaching. manual for studio higher pharmacy tutor shut up - Kharkiv: Golden Pages, 2010. - 600 p.
8. Pulyayev, D.S., Kovalevskaya IV, Chudeshov V.I. Thermogravimetric study of a new medicinal product for the purpose of choosing temperature regimes of the technological process // Zaporozhye Honey. journ - 2010. - No. 2. - P. 118-122.
9. Hung C. F. The effect of oil components on the physicochemical properties and drug delivery of emulsions: tocol emulsion versus lipid emulsion // Int. J. Pharm. - 2007 - Vol. 35, N 1-2. - P. 193-202.
10. Maurice S., Ken A. Emulsions and Oil Treatment Equipment. - Hardbound: Gulf Professional Publishing, 2008. - 304
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