Decomposition kinetics of ion-acetate infusionsolution
Nomenclature infusion of electrolyte solutions , produced in Ukraine is very limited . To date, almost no domestic enterprises produce multicomponent electrolyte solutions that meet the individual needs of patients by the presence of ions and their desired amount. Creating a substantial assortment infusion solutions that satisfy the basic needs of infusion therapy , especially intensive care units is relevant .
The aim of the work was to study the degradation kinetics of ion infusion – acetate solution. The object of investigation was ion infusion solution containing sodium, potassium, calcium , magnesium, chloride and acetate-ions. Research methods were used : pharmacy-technological , kinetic , analytical , statistical. To study the degradation kinetics of ion - acetate solution was made four series of model solution, which was sterilized at 2 - temperatures: at 120 ° C for 15 minutes and at 100 ° C for 30 min.
Experimental results showed that during the storage period there was no significant shift of the reaction medium. Visually, the solutions remained clear and colorless . This demonstrates that both the temperature regime does not lead to degradation of the solution.
Experimental and calculated values of the rate constant , half-life and activation energy showed that the degradation kinetics of the solution passes under pseudo first order reaction , and one of the main factors of degradation factors ion - acetate infusion solution is temperature.
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