Decomposition kinetics of ion-acetate infusionsolution

  • R. S. Koritnyuk National Medical Academy of Post-graduate Education named P. L. Shupyk, Kyiv
  • L. L. Davtyan National Medical Academy of Post-graduate Education named P. L. Shupyk, Kyiv
  • Noor Ahmad Al-Shadat National Medical Academy of Post-graduate Education named P. L. Shupyk, Kyiv
Keywords: decomposition kinetics, ion-acetate infusion solution, temperature, technology, and electrolyte balance

Abstract

Nomenclature infusion of electrolyte solutions , produced in Ukraine is very limited . To date, almost no domestic enterprises produce multicomponent electrolyte solutions that meet the individual needs of patients by the presence of ions and their desired amount. Creating a substantial assortment infusion solutions that satisfy the basic needs of infusion therapy , especially intensive care units is relevant .

The aim of the work was to study the degradation kinetics of ion infusion – acetate solution. The object of investigation was ion infusion solution containing sodium, potassium, calcium , magnesium, chloride and acetate-ions. Research methods were used :  pharmacy-technological , kinetic , analytical , statistical. To study the degradation kinetics of ion - acetate solution was made four series of model solution, which was sterilized at 2 - temperatures: at 120 ° C for 15 minutes and at 100 ° C for 30 min.

Experimental results showed that during the storage period there was no significant shift of the reaction medium. Visually, the solutions remained clear and colorless . This demonstrates that both the temperature regime does not lead to degradation of the solution.

Experimental and calculated values of the rate constant , half-life and activation energy showed that the degradation kinetics of the solution passes under pseudo first order reaction , and one of the main factors of degradation factors ion - acetate infusion solution is temperature.

References

1. Lavrenko AS, Tomenko V. V. Infusion therapy at the prehospital stage. - 2007 - T. 12, No. 5. - P. 81-84.

2. Gumenyuk N. I. Infusion therapy. - 2004 - C. 31-45.

3. Park G., Row P. Infusion Therapy. - Moscow: Binom, 2005. - 134 p.

4. Borisenko T. A., Koritniuk R. S., Davtyan L. L. Study of the influence of some technological techniques on the processes of destruction in an infusion solution with malates / Pharmac. journ - 2009. - No. 4. - P. 104-108.

5. Dmitrievsky D.I., Boguslavskaya D.I., Khokhlova L.M. Technology of medicinal products of industrial production. 2nd form. - Vinnitsa: The New Book, 2008. - 280 p.

6. State Pharmacopoeia of Ukraine. 1st kind. / State Enterprise "Scientific-expert center". - Kharkiv, PIPER, 2001. - 556 pp., Dop. 1st - 2004 - 520 pp., Dop. 2. - 2008 - 620 pp., Dop. 3. - 2009 - 280 pp., Dop. 4th - 2011 - 540 p.

7. State Pharmacopoeia of Ukraine. 1st kind. - Kharkiv: RIREG, DOP. 2. - 2008. - p. 620.

8. Borisenko T. A. Influence of technological factors on the stability of the energy-polyionic solution with malates for infusion therapy / Zb. sciences works of co-workers. NMAPO named after P. L. Shupyk. - K., 2008. - Vo. 18, Kn. 3. - P. 41-48.

9. Encyclopedia of Pharmaceutical Technology, [Third Edition] Editedby James Swarbick. - New York, London: Informahealthcare, 2008. - P. 30.

10. Koritniuk R. S., Borisenko T. A. Influence of the reaction of the medium and the regime of sterilization on the change of pH and light transmission in a polyionic infusion solution // Med. chemistry. - 2008. - Vol. 10, No. 4. - P. 69-71.

11. Korytnyuk R. S., Rudenko V. V., Vlasenko I. O. On the issue of manufacturing drugs for parenteral use in pharmacies of the Communist Party "Pharmacy" in Kyiv / / Pharmac. magazine. - 2006. - No. 1. - P. 42-47.

12. Borisenko T. A., Koritniuk R. S., Davtyan L. L. Technological and physical-chemical control in the manufacture of an infusion solution with malates // Med. chemistry. - 2009. - No. 1. - P. 84-88.

13. Borisenko T. A. Influence of pH and the mode of sterilization on the processes of destruction in polyion glucose-malate solution // Ukr. scientific practice. honey. youth magazine - 2008. - No. 3. - P. 236 237.

14. Zdraykovskaya MV, Torhovaya T.V. Influence of reaction of environment and temperature of sterilization on stability of polyelectrolytic infusion solution with glucose "Glutacin" // Pharmac. a magazine - 2011. - No. 1. - P. 38-42.

15. Korytnyuk R. S., Borisenko T. A. Study of destruction processes in infusion polyion glucose-malate solution // Zaporozhye honey. journ - 2008. - No. 5 (50). - P. 125-127.
Published
2019-02-12
How to Cite
Koritnyuk, R. S., Davtyan, L. L., & Al-Shadat, N. A. (2019). Decomposition kinetics of ion-acetate infusionsolution. Farmatsevtychnyi Zhurnal, (3), 25-28. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/284
Section
Pharmaceutical technology