Rationalization of the approaches to the drugs creation applied for the hypothyroidism fitotherapy
The prophylaxis of iodine deficiency diseases and control for the iodine providing of population in regions with iodine deficiency is the issue of the day today. The medical, social and economic value of iodine deficiency consists in the considerable losses of intellectual, educational and professional potential of nation. Liquidation of iodine deficiency is foreground job for many states in the world, including, and for Ukraine.
One of the most widespread methods of prophylaxis of iodine deficiency diseases is the use of iodized salt, which has a row of failings. For a prophylaxis and treatment of different pathologies of thyroid a certain place is occupied by medical plants and drugs on their basis.
The purpose of work was a theoretical and experimental ground of the methodological approaches of the purposeful search of plants drugs for a prophylaxis and treatment of hypothyroidism, development of possibilities and principles of application of medical plants at these diseases.
On the basis of scientific information and author’s own experimental work the algorithms of targeted search of herbal material objects for prevention and treatment of hypothyroidism have been developed. Basic principles of application of iodine-containing herbs have been formulated.
2. Zelinskaya N. B., Reznikova A. L. Zob in children: clinic, differential diagnosis, treatment // Modern Pediatrics. – 2006. – N 1 (10). – P. 57–66.
3. Parveen S., Latif S. A. Effects of long term iodized table salt consumption on serum T3, T4 and TSH in an iodine deficient // Mymensingh Med. J. – 2007. – V. 16, N 1. – P. 57–60.
4. Petrenko O. D., Pisarenko Yu. M. Experience of prevention of iodine deficiency diseases in the endemic region of Ukraine // Probl. food. – 2009. – N 3–4. – P. 25–28.
5. Pennington J. A. A review of iodine toxicity reports // J. Am. Diet. Assoc. 1990. V. 90. Р. 1571–1581.
6. Delange F. World Status of Monitoring Iodine Deficiency Disorders Control Programs // Thyroid. – 2002. – V. 12, N 10. – Р. 915–924.
7. Dunn J. T. Endemic Goiter and Cretinism: An update on iodine status // J. Pediatric Endocrinol. Metab. – 2001. – V. 14, Suppl. 6. – P. 1469–1473.
8. Korsun V. F., Lobanov K. A. Medicinal plants and hypothyroidism. – М., 2007. – 35 p.
9. Sokolov S. Ya. Phytotherapy and phytopharmacology: hands. for doctors. – M.: Medical Information Agency, 2000. – 976 с.
10. Auf’mkolk M., Kohrle J., Gumbinger H. et al. Antihormonal effects of plant extracts: Iodothyronine deiodinase of rat liver is inhibited by extracts and secondary metabolites of plants // Horm. Metab. Res. 1984. N 16. Р. 188–192.
11. Verhaeghe E. F., Fraysse A., Guerquin-Kern J-L. et al. Microchemical imaging of iodine distribution in the brown alga Laminaria digitata suggests a new mechanism for its accumulation // J. Biol. Inorg. Chem. 2008. V. 13. Р. 257–269.
12. Vladimirova I. M. Standartizatsіya p_dhodіv up to tsіlseprymovany ryuku lіkarskih zosobіv roslinnogo pokzhennya for lіkuvannya zahvoruvan schipopodіbno ї zalozi. Author. dis. ... Dr. pharmac. sciences: 15.00.03. – National Pharmaceutical University, Kharkiv, 2014. – 44 p.
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